E.E. Müller

Peptides and Non Peptides of Oncologic and Neuroendocrine Relevance

From Basic to Clinical Research

• Broschiertes Buch

Produktbeschreibung

Describes the ability of a series of endocrine-derived compounds, i.e. CHRH, LHRH, somatostatin, anti-androgens, and aromatase inhibitors to exert a direct anti-neoplastic activity or to potentiate the activity of traditional chemotherapeutic agents on neuroendocrine and solid tumors. In addition, a new class of potent GH-releasers, GSHs/Ghrelin, endowed with important endocrine and extra-endcocrine action, is presented. Therefore, in addition to traditional chemotherapy, characterized by high toxicity and non-selective action on tumoral cells, the reader can find a new approach with more selective, less cytotoxic endocrine derived compounds.

Produktdetails

• Verlag: Springer / Springer Milan / Springer, Berlin
• Artikelnr. des Verlages: 978-88-470-2170-9
• Softcover reprint of the original 1st ed. 2003
• Seitenzahl: 212
• Erscheinungstermin: 8. Oktober 2012
• Englisch
• Abmessung: 235mm x 155mm x 12mm
• Gewicht: 332g
• ISBN-13: 9788847021709
• ISBN-10: 8847021707
• Artikelnr.: 36935805

Inhaltsangabe

LHRH/SOMATOSTATIN.- Twenty-five years of endocrine oncology with analogs of hypothalamic peptides;. Analogs of luteinizing hormone-releasing hormone (LHRH) in benign prostatic hyperplasia (BPH) and advanced renal cell carcinoma (RCC);. LHRH antagonists in gynecology;. Physiology and pharmacology of somatostatin and its receptors;. Role of LHRH receptor in the control of melanoma growth and progression;. SOMATOSTATIN/GHRH/GH.- Cortistatin revisited;. Antineoplastic and antiangiogenic actions of somatostatin analogs;. Somatostatin in clinical endocrinology;. Antagonists of growth hormone - releasing hormone (GH-RH) in oncology;. GH receptor antagonists: basic knowledge and clinical perspectives;. GHRELIN/GHS.- Ghrelin mimetics (growth hormone secretagogues): interactions with hypothalamic circuits controlling energy balance;. The receptors of growth hormone secretagogues in the cardiovascular system and their physiological functions;. Endocrine and extra-endocrine actions of GHSs: basic studies;. Endocrine and extraendocrine actions of ghrelin and GH synthetic secretagogues: clinical studies;. ANTI-ESTROGENS, ANTI-ANDROGENS, ANTI-PROGESTINS, AROMATASE INHIBITORS IN ONCOLOGY.- Hormonal treatments of endocrine-dependent tumors: preclinical aspects;. Hormonal treatments of endocrine-dependent tumors: clinical aspects;. Aromatase inhibitors;.