Hemorrhage and thrombosis are major hazards for pregnant women and their newborn infants. This book is concerned with the developmental mechanisms, the diagnosis and treatment, as well as the prevention of these hemorrhagic and thrombotic disorders. The topics discussed in this volume, (1) perinatal hemorrhage in mothers and their offspring; (2) coagulation disorders complicating pregnancy; (3) neonatal intracranial hemorrhage; and, (4) vitamin K deficiency in the neonate, will help bridge the gap between basic scientists and clinicians and between the pediatri cian and the obstetrician.…mehr
Hemorrhage and thrombosis are major hazards for pregnant women and their newborn infants. This book is concerned with the developmental mechanisms, the diagnosis and treatment, as well as the prevention of these hemorrhagic and thrombotic disorders. The topics discussed in this volume, (1) perinatal hemorrhage in mothers and their offspring; (2) coagulation disorders complicating pregnancy; (3) neonatal intracranial hemorrhage; and, (4) vitamin K deficiency in the neonate, will help bridge the gap between basic scientists and clinicians and between the pediatri cian and the obstetrician. Hopefully, all those concerned with preventing these disorders will be stimulated by the information and questions raised in the fol lowing presentations. Acknowledgements We wish to thank Professors Takeshi Abe (Vice President, Teikyo University), Nobuyoshi Shinagawa (Hirosaki University), Hiroaki Soma (Tokyo Medical College), Tamotsu Miyazaki and Keisuke Sakurada (Hokkaido University) for theirhelpful advice. SHIGENORI SUZUKI WILLIAM E. HATHAWAY JOHN BONNAR ANTON H. SUTOR SHIGENORI SUZUKI. 1936 in Sapporo, Japan. M.D., Uni 'versity of Hokkaido, 1963. Lecturer, Hokkaido Univer sity, 1974. Alexander Humboldt-Foundation Scholarship, Free University of Berlin. University of Munich, 1974- 1976. Foriner President, Japanese Society of Obstetrical, Gynecological, and Neonatal Hematology. President of International Symposium on Perinatal Thrombosis and Hemostasis (1989 Sapporo). Professor, College of Medi cal Technology affiliated with Hokkaido University since 1983. WILLIAM E. HATHAWAY. 1929 in Oklahoma, USA.
The perinatal period connects problems of the mother and pregnancy with the newborn and birth. These latest reports examine the problems of thrombosis and hemostasis during this period.
Inhaltsangabe
1. Perinatal Hemorrhage in Mothers and Newborns (Diagnosis, Treatment, and Case Reports).- Diagnostic Value of Fibrin- and Fibrinogen Degradation Products in Perinatology.- 1.1 The Diagnostic Value of Fibrin- and Fibrinogen Degradation Products in Perinatology.- 1.2 Bedside Diagnosis of Acute Obstetrical DIC.- 1.3 Analysis of ?-? Dimer and Factor XIII (Fibrin Stabilizing Factor, FSF) During Pregnancy and Labor.- 1.4 Perinatal Emergencies in Sapporo Medical College.- 1.5 Can We Predict Bleeding in Pregnancy? Computer Graphic Analysis of Obstetric Bleeding.- AT III.- 1.6 AT III in Pregnancy and Newborn Infants.- 1.7 Thrombin-Antithrombin III Complex and D-Dimer in Neonates: Signs of Thrombin Generation During Birth.- 1.8 Effect of Antithrombin III Concentrate for DIC in Obstetrics and Gynecology: The Changes of Prostanoids in Plasma Before and After Administration.- Perinatal Coagulation and Fibrinolysis.- 1.9 Perinatal Coagulation and Fibrinolysis.- 1.10 The Relationship Between the Onset of Labor Mechanisms and the Blood Coagulation System.- 1.11 Perinatal Problems of Thrombosis and Hemostasis.- The Coagulation System in the Newborn Infant.- 1.12 Anticoagulant and Thrombolytic Therapy in the Newborn.- 1.13 Regulatory Mechanisms Controlling Prothrombin and the Development of Blood Coagulation Factors During Gestation.- 1.14 Neonatal Thrombosis: A Critical Appraisal of the Available Evidence on Prevention, Diagnosis, and Treatment.- 2. Pregnancy Complicated with Coagulation Disorders.- Trophoblastic Disease, Placenta, etc..- 2.1 Coagulation and Fibrinolytic Activity in Trophoblastic Disease.- 2.2 Placental Protein 19 in Clinical Blood Coagulation Disorder.- 2.3 Platelet Aggregation Inhibition Activity of Placental Brush Border Membrane.- Coagulation Disorders During thePerinatal Period.- 2.4 Hematopoietic Malignancies During the Perinatal Period.- 2.5 Thrombocytopenia Associated with Type IIB von Willebrand's Disease of Pregnant Identical Twins.- ITP During Pregnancy.- 2.6 Management of Pregnancy Complicated with Idiopathic Thrombocytopenic Purpura: A Review of 16 Cases.- 2.7 The Management of Immunologic Thrombocytopenic Purpura (ITP) During Pregnancy.- 2.8 Thrombocytopenia in Pregnancy.- 3. Brain Hemorrhage (Including Vitamin K Deficiency).- Basic Research of Hemostasis During the Perinatal Period.- 3.1 Absorption, Metabolism and Storage of K Vitamins in the Newborn.- 3.2 Vitamin K1 and K2 Contents in Blood, Stool and Liver Tissues of Neonates and Young Infants.- 3.3 The Role of Hemostasis in Neonatal Intracranial Hemorrhage.- Vitamin K Deficiency 1.- 3.4 Vitamin K Prophylaxis and Late Onset Hemorrhagic Disease of the Newborn in West Germany During 1988.- 3.5 Vitamin K Deficiency and Breast-Feeding.- Vitamin K Deficiency 2.- 3.6 The Third Nationwide Survey on Vitamin K Deficiency in Infancy in Japan.- 3.7 Time Interval Between Vitamin K Administration and Effective Hemostasis.- 3.8 Effect of Vitamin K Prophylaxis on the Incidence of the Late Form of Vitamin Deficiency Bleeding.- Intracranial Hemorrhage.- 3.9 Antithrombin III Administration in Premature Infants with Intracranial Hemorrhage.- 3.10 Six Cases of Alpha-1-Antitrypsin Deficiency Presenting as a Bleeding Diathesis with Intracranial Hemorrhage in the Newborn.
1. Perinatal Hemorrhage in Mothers and Newborns (Diagnosis, Treatment, and Case Reports).- Diagnostic Value of Fibrin- and Fibrinogen Degradation Products in Perinatology.- 1.1 The Diagnostic Value of Fibrin- and Fibrinogen Degradation Products in Perinatology.- 1.2 Bedside Diagnosis of Acute Obstetrical DIC.- 1.3 Analysis of ?-? Dimer and Factor XIII (Fibrin Stabilizing Factor, FSF) During Pregnancy and Labor.- 1.4 Perinatal Emergencies in Sapporo Medical College.- 1.5 Can We Predict Bleeding in Pregnancy? Computer Graphic Analysis of Obstetric Bleeding.- AT III.- 1.6 AT III in Pregnancy and Newborn Infants.- 1.7 Thrombin-Antithrombin III Complex and D-Dimer in Neonates: Signs of Thrombin Generation During Birth.- 1.8 Effect of Antithrombin III Concentrate for DIC in Obstetrics and Gynecology: The Changes of Prostanoids in Plasma Before and After Administration.- Perinatal Coagulation and Fibrinolysis.- 1.9 Perinatal Coagulation and Fibrinolysis.- 1.10 The Relationship Between the Onset of Labor Mechanisms and the Blood Coagulation System.- 1.11 Perinatal Problems of Thrombosis and Hemostasis.- The Coagulation System in the Newborn Infant.- 1.12 Anticoagulant and Thrombolytic Therapy in the Newborn.- 1.13 Regulatory Mechanisms Controlling Prothrombin and the Development of Blood Coagulation Factors During Gestation.- 1.14 Neonatal Thrombosis: A Critical Appraisal of the Available Evidence on Prevention, Diagnosis, and Treatment.- 2. Pregnancy Complicated with Coagulation Disorders.- Trophoblastic Disease, Placenta, etc..- 2.1 Coagulation and Fibrinolytic Activity in Trophoblastic Disease.- 2.2 Placental Protein 19 in Clinical Blood Coagulation Disorder.- 2.3 Platelet Aggregation Inhibition Activity of Placental Brush Border Membrane.- Coagulation Disorders During thePerinatal Period.- 2.4 Hematopoietic Malignancies During the Perinatal Period.- 2.5 Thrombocytopenia Associated with Type IIB von Willebrand's Disease of Pregnant Identical Twins.- ITP During Pregnancy.- 2.6 Management of Pregnancy Complicated with Idiopathic Thrombocytopenic Purpura: A Review of 16 Cases.- 2.7 The Management of Immunologic Thrombocytopenic Purpura (ITP) During Pregnancy.- 2.8 Thrombocytopenia in Pregnancy.- 3. Brain Hemorrhage (Including Vitamin K Deficiency).- Basic Research of Hemostasis During the Perinatal Period.- 3.1 Absorption, Metabolism and Storage of K Vitamins in the Newborn.- 3.2 Vitamin K1 and K2 Contents in Blood, Stool and Liver Tissues of Neonates and Young Infants.- 3.3 The Role of Hemostasis in Neonatal Intracranial Hemorrhage.- Vitamin K Deficiency 1.- 3.4 Vitamin K Prophylaxis and Late Onset Hemorrhagic Disease of the Newborn in West Germany During 1988.- 3.5 Vitamin K Deficiency and Breast-Feeding.- Vitamin K Deficiency 2.- 3.6 The Third Nationwide Survey on Vitamin K Deficiency in Infancy in Japan.- 3.7 Time Interval Between Vitamin K Administration and Effective Hemostasis.- 3.8 Effect of Vitamin K Prophylaxis on the Incidence of the Late Form of Vitamin Deficiency Bleeding.- Intracranial Hemorrhage.- 3.9 Antithrombin III Administration in Premature Infants with Intracranial Hemorrhage.- 3.10 Six Cases of Alpha-1-Antitrypsin Deficiency Presenting as a Bleeding Diathesis with Intracranial Hemorrhage in the Newborn.
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