Periodontal wound healing certainly is considered a more complex process compared to the epidermal wound healing. The native Periodontium includes a cementum, a functionally oriented PDL, alveolar bone, and the gingiva. The interface between these tissues as well as the transgingival position of the tooth represent a constant challenge during the restoration of the integrity of the native structures as they seek to create a new connection to the non-vascular and non-vital hard tissue of the root surface within the context of an open system that is permanently contaminated and under a significant "bacterial load". It is therefore not surprising that the healing that results following all types of gingival and periodontal therapy can be quite variable.