Brian E. Cairns

Peripheral Receptor Targets for Analgesia

Novel Approaches to Pain Management

• Gebundenes Buch

Produktbeschreibung

Peripheral Receptor Targets for Analgesia reviews the role of peripheral receptor mechanisms in the transduction of pain, providing a framework for the development of new and effective rationally designed analgesic drugs and therapies with and promoting further basic and clinical studies on potentially interesting peripheral receptor targets. It uniquely brings together in one text the diverse body of work on peripheral receptor mechanisms of pain. This comprehensive reference aids pharmaceutical scientists, pharmacologists, and neuroscientists developing drugs and researching pain in achieving selectivity in drug therapy for more efficient pain management.

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Produktdetails

• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 549
• Erscheinungstermin: 1. August 2009
• Englisch
• Abmessung: 240mm x 161mm x 35mm
• Gewicht: 884g
• ISBN-13: 9780470251317
• ISBN-10: 047025131X
• Artikelnr.: 26487938

Autorenporträt

Brian Cairns is Canada Research Chair in Neuropharmacology and an Associate Professor in the Faculty of Pharmaceutical Sciences at the University of British Columbia. The author of book chapters (including in Wiley's Handbook of Pharmaceutical Biotechnology) and more than fifty journal articles, Dr. Cairns also teaches undergraduate and graduate students about pain research and treatment, and contributes to the activities of several well-known pain research societies.

Inhaltsangabe

FOREWORD by Lars Arendt-Nielsen.
PREFACE.
CONTRIBUTORS.
PART I PERIPHERAL MECHANISM IN CLINICAL PAIN CONDITIONS.
1. Role of Peripheral Mechanisms in Craniofacial Pain Conditions (Barry J.
Sessle).
2. Role of Peripheral Mechanisms in Spinal Pain Conditions (Brian E. Cairns
and Pradit Prateepavanich).
PART II SPECIFIC RECEPTOR TARGETS FOR PERIPHERAL ANALGESICS.
3. Voltage-Gated Sodium Channels in Peripheral Nociceptive Neurons as
Targets For the Treatment of Pain (Theodore R. Cummins).
4. Potassium Channels (Daisuke Nishizawa1, Toru Kobayashi, and Kazutaka
Ikeda).
5. Voltage-Gated Calcium Channels as Targets for the Treatment of Chronic
Pain (Joe McGivern).
6. Adenosine Receptors (Jana Sawynok).
7. Acid-Sensing Ion Channels and Pain (Roxanne Y. Walder, Christopher J.
Benson and Kathleen A. Sluka).
8. Vanilloid (TRPV1) and Other Transient Receptor Potential Channels (
Marcello Trevisani and Arpad Szallasi).
9. Glutamate Receptors (Brian E. Cairns).
10. Serotonin Receptors (Malin Ernberg).
11. Adrenergic Receptors (Antti Pertovaara).
12. Cholinergic Receptors and Botulinum Toxin (Parisa Gazerani).
13. Cannabinoids and Pain Control in the Periphery (Jason J. McDougall).
14. Opioid Receptors (Claudia Herrera Tambeli, Luana Fischer and Carlos
Amilcar Parada).
15. Calcitonin Gene-Related Peptide and Substance P (Ranjinidevi
Ambalavanar and Dean Dessem).
16. Role of Somatostatin and Somatostatin Receptors in Pain (Ujendra Kumar
).
17. Cytokines (Tumor Necrosis Factor, Interleukins) and Prostaglandins (
Per Alstergren).
18. Neurotrophic Factors and Pain (Peter Svensson).
PART III DELIVERY SYSTEMS.
19. Topical and Systemic Drug Delivery Systems Targeted Drug Therapy (Urs
Hafeli and Amit Kale).
20. Gene Therapy for Pain (Marina Mata and David J. Fink).
21. Topical Analgesics (Akhlaq Waheed Hakim and Brian E. Cairns).
Index.