H. Brian Dunford, Peter A. Jones

Peroxidases and Catalases

• Gebundenes Buch

Produktbeschreibung

Single source guide to peroxidases and catalases
Reflecting the important historical discoveries and exciting research in the field in recent years, Peroxidases and Catalases: Biochemistry, Biophysics, Biotechnology and Physiology provides a much-needed systematic, up-to-date treatment of peroxidases and catalases.
From the structure and properties of the various superfamilies to current applications of peroxidases, the book consolidates vast amounts of information previously scattered in the professional literature, covering all aspects of these ubiquitous enzymes that act on a variety of substances and processes in living systems-their properties, reactions, crystal structures, cloning, and more.
Considering the subject from both theoretical and applied perspectives, Peroxidases and Catalases offers a critical review of the literature and detailed discussions of the most current research. Chapters cover:
The background and history of peroxidases and catalases
Plant, fungal, and bacterial peroxidase superfamilies and their organization
Mammalian peroxidases including medical and physiological roles
Spectroscopic and theoretical techniques for studying peroxidases highlighting the contributions of physicists and physical/theoretical chemists
Heme peroxidases, catalases, and other peroxidases such as vanadium and selenium peroxidase
Relevant plant and animal physiology
This one-stop reference is a vital reference for biochemists, biologists, biochemical engineers, physiologists, environmental and pharmaceutical researchers, and others interested in the study and use of peroxidases and catalases. Peroxidases and Catalases provides a summary of current research on peroxidase and catalase enzymes, along with detailed chapters on mammalian peroxidases, medical and physiological roles, as well as spectroscopic and theoretical techniques, enabling biochemists to understand the contributions made principally by physicists and physical/theoretical chemists. Plus, the text discusses heme peroxidases and catalases, as well as other peroxidases, like vanadium peroxidases and selenium peroxidase. This book is a vital reference on peroxidases and catalases for engineers and researchers.

Produktdetails

• Verlag: Wiley & Sons
• 2. Aufl.
• Seitenzahl: 480
• Erscheinungstermin: 29. März 2010
• Englisch
• Abmessung: 240mm x 161mm x 30mm
• Gewicht: 877g
• ISBN-13: 9780470224762
• ISBN-10: 0470224762
• Artikelnr.: 27869510

Autorenporträt

H. BRIAN DUNFORD, PHD, is a biophysical chemist currently working on peroxidase enzymes and Professor Emeritus at the University of Alberta. He received his PhD from McGill University. He is the author of Heme Peroxidases, editor of other books, as well as coauthor of more than 250 journal articles.

Inhaltsangabe

Preface. 1 Historical Pioneering work on horseradish and yeast cytochrome c
peroxidases. Introduction. Techniques and instrumentation. Conclusions. 2
Heme peroxidase and catalase families. Plant, fungal and bacterial
peroxidases. Mammalian peroxidases. Catalases. 3 Horseradish peroxidase I.
The native enzyme, Compounds I and II, their structures and their cycle.
Introduction. The classic peroxidase cycle. Structure and properties of
native horseradish peroxidase C. Horseradish peroxidase Compound I (HRP-I).
Horseradish peroxidase Compound II (HRP-II). Some diverse approaches to an
understanding of horseradish peroxidase. 4 Horseradish peroxidase II.
Two-electron reactions, ferrous peroxidase, Compound III, the five
oxidation states, oxygen evolution, and inactivation. Introduction.
Two-electron oxidations by Compound I. Oxygen transfer by one-electron
mechanisms. Ferrous horseradish peroxidase and Compound III. The five
oxidation states of horseradish peroxidase. The catalatic reaction. The HRP
clock reaction. Enzyme inactivation. 5 Horseradish peroxidase III.
Oscillations and peroxidase-oxidase reactions with NADH, indole-3-acetic
acid and isobutyraldehyde. Oscillations and the NADH peroxidase-oxidase
reaction. Peroxidase-oxidase reaction with indole-3-acetic acid. Reaction
of isobutyraldehyde with horseradish peroxidase. 6 Yeast cytochrome c
peroxidase. Reactions with small substrates. Introduction. Properties of
yeast cytochrome c peroxidase. Crystal structures of yeast cytochrome c
peroxidase, its compounds and complexes. Mechanism of Compound I formation.
The reaction cycle for yeast cytochrome c peroxidase. Steady state
kinetics. 7 Yeast cytochrome c peroxidase. Reaction with cytochrome c.
Introduction. Experimental results. 8 Spectroscopy I. Optical, resonance
Raman, and X-ray absorption. Optical absorption spectroscopy. Resonance
Raman spectra. X-ray absorption spectroscopy. 9 Spectroscopy II. Nuclear
magnetic resonance, electron spin, and M"ssbauer. Nuclear magnetic
resonance (NMR) spectroscopy. Electron spin resonance (ESR) spectroscopy.
M"ssbauer spectroscopy. 10 Theoretical. Peroxidase kinetics. Marcus theory
for electron transfer reactions. Electron tunneling. Electron transfer
reactions in proteins. Electron density circuits. Diffusion control.
Quantum mechanical calculations. 11 Class I: ascorbate peroxidase.
Ascorbate peroxidase. 12 Catalase-peroxidases and Mycobacterium
tuberculosis. Introduction. Structures of catalase-peroxidases. Isoniazid
and other reactants of catalase-peroxidases. The oxidative defence
mechanisms of Mycobacterium tuberculosis. 13 Class II. Lignin, manganese,
versatile, and Coprinus cinereus peroxidases. Lignin peroxidase. Manganese
peroxidase. Other manganese peroxidases, versatile peroxidase. Coprinus
cinereus (Arthromyces ramosus) peroxidase. 14 Other Class III peroxidases.
Arabidopsis thaliana peroxidase. Barley peroxidase. Peanut peroxidase.
Soybean peroxidase. Tobacco peroxidases. Turnip peroxidases. 15 Catalases.
Preamble. Perspective. Progress. Catalases in biology. Prospects. 16
Myeloperoxidase. Enzymology. Introduction. Properties of myeloperoxidase.
The compounds of myeloperoxidase. Reactions of myeloperoxidase. Cloning of
myeloperoxidase. Site-directed mutagenesis. The crystal structure and
prosthetic group of myeloperoxidase. Eosinophil peroxidase. 17 Biomedical
aspects of myeloperoxidase. Halogenation reactions in cardiovascular
disease, infection and cancer. Introduction. Oxidants produced by MPO in
humans. MPO and coronary artery disease. MPO and carcinogenesis. Prospects.
18 Prostaglandin H synthase. Introduction. Crystal structures.
Prostaglandin H synthase-2. Preliminary mechanistic studies. Detection of
free radicals: role of ESR spectroscopy. The role of aspirin and related
substances: Contributions of Vane and Smith. Work of Marnett and coworkers.
Work of Kulmacz, Tsai and coworkers. Manganese prostaglandin synthases.
Mechanistic details. 19 Thyroid peroxidase. Introduction. Hormone discovery
and chemical synthesis. Detection of the method of biological synthesis of
thyroxine. Conclusions. 20 Lacto- and salivary peroxidases. Introduction.
The compounds of lactoperoxidase and their reactions. 21 Heme
chloroperoxidase from C. fumago. Introduction. Optical spectra. ESR, ENDOR,
M"ssbauer, EXAFS and resonance Raman spectra. Structure of Compound I and
the catalatic reaction. Ligand binding. Kinetics and mechanism of
chlorination and oxidation. Amino acid sequence and crystal structure. 22
Selenium-containing enzymes: glutathione peroxidase and iodothyronine
deiodinase. Introduction. Glutathione peroxidase. Iodothyronine deiodinase.
23 Structure and function of vanadium peroxidases. Summary. Introduction.
Occurrence and biological function of vanadium iodo- and bromoperoxidases.
Catalytic properties of BPO. Properties of the prosthetic group in
bromoperoxidase. Kinetic and optical properties of vanadium
chloroperoxidases. Sulfoxidation reactions. Stability of bromo- and
chloroperoxidases. X-ray structures of vanadium bromoperoxidases. Active
site of vanadium bromoperoxidase from A. nodsum. X-ray structure of the
peroxy-intermediate of vanadium chloroperoxidase. Nature of the vanadate
cofactor. 24 Other heme peroxidases and enzymes. Di-heme peroxidases.
Peroxidases everywhere you look. Myoglobins. Hemoglobin. Cytochrome c
oxidase. Oxygenases. Heme oxygenase. Guanylyl cyclase. 25 Application of
peroxidases. Introduction. Background information. Peroxidases as
pharmaceutical and/or antimicrobial agents. Applications in bleaching and
detergents. Biotransformations. Polymerization reactions and waste water
purification. Depolymerization reactions. Analytical applications. Medical
applications.