Foreword; Introduction; Part I. Basic Principles: 1. Principles of quantitative clinical pharmacology Pedro L Gambús and Sebastián Jaramillo; 2. Pharmacokinetic and pharmacodynamic modeling in anaesthesia María J. Garrido and Iñaki F. Trocóniz; 3. Drug interactions: additivity and synergy among anaesthetic drugs Jacqueline A. Hannam and Timothy G. Short; 4. Covariate analysis in clinical anaesthesia Luis I. Cortinez and Brian J. Anderson; 5. Signal analysis and response measurement Umberto Melia, Erik W. Jensen and José F. Valencia; 6. Application of PKPD and signal analysis to drug administration in anaesthesia Ross R. Kennedy; Part II. Targeting Effects: 7. Hypnotic effect: inducing unconsciousness and emergence from anaesthesia Sergio Vide, Catarina Nunes and Pedro Amorim; 8. Analgesia: effects on response to nociceptive stimulation Emmanuel Boselli and Mathieu Jeanne; 9. Personalized sedation and analgesia Michael M. Beck, Jeffrey B. Horn and Ken B. Johnson; 10. Respiratory depression Malin Jonsson Fagerlund; 11. Immobility Klaus T. Olkkola and Douglas J. Eleveld; 12. Effects on brain function Neus Fabregas and Adrian W. Gelb; 13. Targeted and individualized perioperative medicine for cognitive dysfunction Pauline Glasman, Alice Jacquens and Vincent Degos; 14. Cardiac and hemodynamic function Kai Kuck, Natalie Silverton and Michael K. Cahalan; 15. Effects of anaesthesia on thermoregulation Oliver Kimberger; 16. Effects of perioperative management on kidney function Xavier Borrat and Jordi Mercadal; 17. Effects on liver function Andre M. De Wolf and Jan F. A. Hendrickx; 18. Effects on fluid balance Robert G. Hahn; 19. Ventilation during general anaesthesia Lluís Gallart; 20. Epilogue: artificial intelligence methods Sebastián Jaramillo, José F. Valencia and Pedro L. Gambús; Index.
Foreword; Introduction; Part I. Basic Principles: 1. Principles of quantitative clinical pharmacology Pedro L Gambús and Sebastián Jaramillo; 2. Pharmacokinetic and pharmacodynamic modeling in anaesthesia María J. Garrido and Iñaki F. Trocóniz; 3. Drug interactions: additivity and synergy among anaesthetic drugs Jacqueline A. Hannam and Timothy G. Short; 4. Covariate analysis in clinical anaesthesia Luis I. Cortinez and Brian J. Anderson; 5. Signal analysis and response measurement Umberto Melia, Erik W. Jensen and José F. Valencia; 6. Application of PKPD and signal analysis to drug administration in anaesthesia Ross R. Kennedy; Part II. Targeting Effects: 7. Hypnotic effect: inducing unconsciousness and emergence from anaesthesia Sergio Vide, Catarina Nunes and Pedro Amorim; 8. Analgesia: effects on response to nociceptive stimulation Emmanuel Boselli and Mathieu Jeanne; 9. Personalized sedation and analgesia Michael M. Beck, Jeffrey B. Horn and Ken B. Johnson; 10. Respiratory depression Malin Jonsson Fagerlund; 11. Immobility Klaus T. Olkkola and Douglas J. Eleveld; 12. Effects on brain function Neus Fabregas and Adrian W. Gelb; 13. Targeted and individualized perioperative medicine for cognitive dysfunction Pauline Glasman, Alice Jacquens and Vincent Degos; 14. Cardiac and hemodynamic function Kai Kuck, Natalie Silverton and Michael K. Cahalan; 15. Effects of anaesthesia on thermoregulation Oliver Kimberger; 16. Effects of perioperative management on kidney function Xavier Borrat and Jordi Mercadal; 17. Effects on liver function Andre M. De Wolf and Jan F. A. Hendrickx; 18. Effects on fluid balance Robert G. Hahn; 19. Ventilation during general anaesthesia Lluís Gallart; 20. Epilogue: artificial intelligence methods Sebastián Jaramillo, José F. Valencia and Pedro L. Gambús; Index.
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