Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug…mehr
Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy.
The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics.
Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.
Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O'Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor's degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Resear
ch (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.
Inhaltsangabe
Section I: Overview
1. Epigenetics of Personalized Medicine
Section II: Epigenetic Variations Among Individuals
2. Inter-individual Variability of DNA Methylation
3. Differences in Histone Modifications Between Individuals
4. Individual Noncoding RNA Variations: Their Role in Shaping and Maintaining the Epigenetic Landscape
5. Personalized Epigenetics: Analysis and Interpretation of DNA Methylation Variation
Section III: Bioinformatics of Personalized Epigenetics
6. Computational Methods in Epigenetics
Section IV: Diagnostic and Prognostic Epigenetic Approaches to Personalized Medicine
7. Epigenetic Biomarkers in Personalized Medicine
8. Epigenetic 'Fingerprint'
9. Epigenetics of Personalized Toxicology
Section V: Environmental Personalized Epigenetics
10. Environmental Contaminants and their Impacts on the Epigenome
