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In diesem Tagungsband stellen Ihnen die Hauptvortragenden des '13th World Congress on Animal, Plant and Microbial Toxins' neueste Entwicklungen auf ihren jeweiligen Fachgebieten vor. Das Themenspektrum reflektiert momentane Forschungsschwerpunkte - die meisten Beiträge beschäftigen sich mit neuartigen Toxinen, die im Meer gefunden wurden.
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In diesem Tagungsband stellen Ihnen die Hauptvortragenden des '13th World Congress on Animal, Plant and Microbial Toxins' neueste Entwicklungen auf ihren jeweiligen Fachgebieten vor. Das Themenspektrum reflektiert momentane Forschungsschwerpunkte - die meisten Beiträge beschäftigen sich mit neuartigen Toxinen, die im Meer gefunden wurden.
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Produktdetails
- Produktdetails
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 516
- Erscheinungstermin: 17. Mai 2002
- Englisch
- Abmessung: 231mm x 161mm x 34mm
- Gewicht: 880g
- ISBN-13: 9780471495031
- ISBN-10: 0471495034
- Artikelnr.: 10524261
- Herstellerkennzeichnung
- Libri GmbH
- Europaallee 1
- 36244 Bad Hersfeld
- 06621 890
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 516
- Erscheinungstermin: 17. Mai 2002
- Englisch
- Abmessung: 231mm x 161mm x 34mm
- Gewicht: 880g
- ISBN-13: 9780471495031
- ISBN-10: 0471495034
- Artikelnr.: 10524261
- Herstellerkennzeichnung
- Libri GmbH
- Europaallee 1
- 36244 Bad Hersfeld
- 06621 890
Andre Menez is the Director of the Department of Protein Engineering at the Commissariat a l'Energie Atomique (CEA) in France. He heads the Laboratory of Protein Chemistry and is Professor at the National Institute of Sciences and Nuclear Techniques.
List of Contributors
Preface
I TOXINS FROM MICROORGANISMS
Bacterial Toxins with Metalloprotease Activity (O. Rossetto and C.
Montecucco)
The Cholesterol-dependent Cytolysins: Current Perspectives on Membrane
Assembly and Insertion (E. Hotze and R.K. Tweten)
Toxin-producing Dinoflagellates (M.J. Holmes and R. Lewis)
Involvement of Na+ in the Actions of Ciguatoxins and Brevetoxins that
Stimulate Neurotransmitter Release and Affect Synaptic Transmission (J.
Molgó and E. Benoit)
II ANIMAL TOXINS AND NEW METHODOLOGIES
Role of Discovery Science in Toxicology: Examples in Venom Proteomics (J.W.
Fox, J.D. Shannon, B. Stefansson, A.S. Kamiguti, R.D.G. Theakston, S.M.T.
Serrano, A.C.M. Camargo and N. Sherman)
Proteomics of Venom Peptides (R. Stocklin and P. Favreau)
High-resolution NMR of Venom Toxins in Nanomolar Amounts (M. Delepierre)
III ANIMAL TOXINS: FROM FUNDAMENTAL STUDIES TO DRUGS?
Cone Snails and Conotoxins Evolving Sophisticated Neuropharmacology (B.M.
Olivera, J.S. Imperial and G Bulaj)
Toxin Structure and Function: What Does Structural Genomics Have To Offer?
(R.S. Norton)
The Sites by which Animal Toxins Bind to their Targets Involve Two
Components: A Clue for Selectivity, Evolution and Design of Proteins? (A.
Ménez, D. Servent and S. Gasparini)
Scorpion Genes and Peptides Specific for Potassium Channels:
Structure,Function and Evolution (L.D. Possani, E. Merino, M. Corona and B.
Becerril)
Scorpion Toxins Differentiating among Neuronal Sodium Channel Subtypes:
Nature's Guide for Design of Selective Drugs (D. Gordon, N. Gilles, D.
Bertrand, J. Molgó, G.M. Nicholson, M.P. Sauviat, E. Benoit, I. Shichor, I.
Lotan, M. Gurevitz, R.G. Kallen and S.H. Heinemann)
Diversification of Toxic Sites on a Conserved Protein Scaffold - a Scorpion
Recipe for Survival (M. Gurevitz, N. Zilberberg, O. Froy, M. Turkov, R.
Wilunsky, I. Karbat, J. Anglister, B. Shaanan, M. Pelhate, M.E. Adams, N.
Gilles, D. Gordon)
Methodological Approaches to the Study of Ion Channels Using Peptide
Toxins: Proposed Comprehensive Guidelines (M. De Waard, J.-M. Sabatier and
H. Rochat)
Toxins as Probes for Structure and Specificity of Synaptic Target Proteins
(P. Taylor, B. Molles, S. Malany and H. Osaka)
Allosteric and Steric interactions of Polyamines and Polyamine-containing
Toxins with Nicotinic Acetylcholine Receptors (T.J. Brier, I.R. Mellor and
P.N.R. Usherwood)
Anabaseine as a Molecular Model for Design of a7 Nicotinic Receptor Agonist
Drugs (W.R. Kem)
Understanding the Structure-Function Relationship of Snake Venom
Cardiotoxins (T.K.S. Kumar, S. Srisailam, R.R. Vethanayagam and C. Yu)
Structure and Function of Disintegrins and C-lectins: Viper Venom Proteins
Modulating Cell Adhesion (S. Niewiarowski, C. Marcinkiewicz, I.
Wierzbicka-Patynowski, M.A. McLane and J.J. Calvete)
Prothrombin Activators from Snake Venoms (R.M. Kini, J.S. Joseph and V.S.
Rao)
C-type Lectins from Snake Venoms: New Tools for Research in Thrombosis and
Haemostasis (A. Wisner, M. Leduc and C. Bon)
Toxins Leading to Medicines (A.L. Harvey)
IV EVOLUTION OF ANIMAL TOXINS
Accelerated and Regional Evolution of Snake Venom Gland Isozymes (M. Ohno,
T. Ogawa, N. Oda-Ueda, T. Chijiwa and S. Hattori)
Functional Diversification of Animal Toxins by Adaptive Evolution (D.
Kordis, I. Kriûaj and F. Gubenëek)
V FROM VENOMS TO TREATMENT
The Venomous Function (M. Goyffon)
Are Inhibitors of Metalloproteinases, Phospholipases A2 and Myotoxins
Members of the Innate System? (J. Perales and G.B. Domont)
The Treatment of Snake Bites: Analysis of Requirements and Assessment of
Therapeutic Efficacy in Tropical Africa (J.-P. Chippaux)
Preface
I TOXINS FROM MICROORGANISMS
Bacterial Toxins with Metalloprotease Activity (O. Rossetto and C.
Montecucco)
The Cholesterol-dependent Cytolysins: Current Perspectives on Membrane
Assembly and Insertion (E. Hotze and R.K. Tweten)
Toxin-producing Dinoflagellates (M.J. Holmes and R. Lewis)
Involvement of Na+ in the Actions of Ciguatoxins and Brevetoxins that
Stimulate Neurotransmitter Release and Affect Synaptic Transmission (J.
Molgó and E. Benoit)
II ANIMAL TOXINS AND NEW METHODOLOGIES
Role of Discovery Science in Toxicology: Examples in Venom Proteomics (J.W.
Fox, J.D. Shannon, B. Stefansson, A.S. Kamiguti, R.D.G. Theakston, S.M.T.
Serrano, A.C.M. Camargo and N. Sherman)
Proteomics of Venom Peptides (R. Stocklin and P. Favreau)
High-resolution NMR of Venom Toxins in Nanomolar Amounts (M. Delepierre)
III ANIMAL TOXINS: FROM FUNDAMENTAL STUDIES TO DRUGS?
Cone Snails and Conotoxins Evolving Sophisticated Neuropharmacology (B.M.
Olivera, J.S. Imperial and G Bulaj)
Toxin Structure and Function: What Does Structural Genomics Have To Offer?
(R.S. Norton)
The Sites by which Animal Toxins Bind to their Targets Involve Two
Components: A Clue for Selectivity, Evolution and Design of Proteins? (A.
Ménez, D. Servent and S. Gasparini)
Scorpion Genes and Peptides Specific for Potassium Channels:
Structure,Function and Evolution (L.D. Possani, E. Merino, M. Corona and B.
Becerril)
Scorpion Toxins Differentiating among Neuronal Sodium Channel Subtypes:
Nature's Guide for Design of Selective Drugs (D. Gordon, N. Gilles, D.
Bertrand, J. Molgó, G.M. Nicholson, M.P. Sauviat, E. Benoit, I. Shichor, I.
Lotan, M. Gurevitz, R.G. Kallen and S.H. Heinemann)
Diversification of Toxic Sites on a Conserved Protein Scaffold - a Scorpion
Recipe for Survival (M. Gurevitz, N. Zilberberg, O. Froy, M. Turkov, R.
Wilunsky, I. Karbat, J. Anglister, B. Shaanan, M. Pelhate, M.E. Adams, N.
Gilles, D. Gordon)
Methodological Approaches to the Study of Ion Channels Using Peptide
Toxins: Proposed Comprehensive Guidelines (M. De Waard, J.-M. Sabatier and
H. Rochat)
Toxins as Probes for Structure and Specificity of Synaptic Target Proteins
(P. Taylor, B. Molles, S. Malany and H. Osaka)
Allosteric and Steric interactions of Polyamines and Polyamine-containing
Toxins with Nicotinic Acetylcholine Receptors (T.J. Brier, I.R. Mellor and
P.N.R. Usherwood)
Anabaseine as a Molecular Model for Design of a7 Nicotinic Receptor Agonist
Drugs (W.R. Kem)
Understanding the Structure-Function Relationship of Snake Venom
Cardiotoxins (T.K.S. Kumar, S. Srisailam, R.R. Vethanayagam and C. Yu)
Structure and Function of Disintegrins and C-lectins: Viper Venom Proteins
Modulating Cell Adhesion (S. Niewiarowski, C. Marcinkiewicz, I.
Wierzbicka-Patynowski, M.A. McLane and J.J. Calvete)
Prothrombin Activators from Snake Venoms (R.M. Kini, J.S. Joseph and V.S.
Rao)
C-type Lectins from Snake Venoms: New Tools for Research in Thrombosis and
Haemostasis (A. Wisner, M. Leduc and C. Bon)
Toxins Leading to Medicines (A.L. Harvey)
IV EVOLUTION OF ANIMAL TOXINS
Accelerated and Regional Evolution of Snake Venom Gland Isozymes (M. Ohno,
T. Ogawa, N. Oda-Ueda, T. Chijiwa and S. Hattori)
Functional Diversification of Animal Toxins by Adaptive Evolution (D.
Kordis, I. Kriûaj and F. Gubenëek)
V FROM VENOMS TO TREATMENT
The Venomous Function (M. Goyffon)
Are Inhibitors of Metalloproteinases, Phospholipases A2 and Myotoxins
Members of the Innate System? (J. Perales and G.B. Domont)
The Treatment of Snake Bites: Analysis of Requirements and Assessment of
Therapeutic Efficacy in Tropical Africa (J.-P. Chippaux)
List of Contributors
Preface
I TOXINS FROM MICROORGANISMS
Bacterial Toxins with Metalloprotease Activity (O. Rossetto and C.
Montecucco)
The Cholesterol-dependent Cytolysins: Current Perspectives on Membrane
Assembly and Insertion (E. Hotze and R.K. Tweten)
Toxin-producing Dinoflagellates (M.J. Holmes and R. Lewis)
Involvement of Na+ in the Actions of Ciguatoxins and Brevetoxins that
Stimulate Neurotransmitter Release and Affect Synaptic Transmission (J.
Molgó and E. Benoit)
II ANIMAL TOXINS AND NEW METHODOLOGIES
Role of Discovery Science in Toxicology: Examples in Venom Proteomics (J.W.
Fox, J.D. Shannon, B. Stefansson, A.S. Kamiguti, R.D.G. Theakston, S.M.T.
Serrano, A.C.M. Camargo and N. Sherman)
Proteomics of Venom Peptides (R. Stocklin and P. Favreau)
High-resolution NMR of Venom Toxins in Nanomolar Amounts (M. Delepierre)
III ANIMAL TOXINS: FROM FUNDAMENTAL STUDIES TO DRUGS?
Cone Snails and Conotoxins Evolving Sophisticated Neuropharmacology (B.M.
Olivera, J.S. Imperial and G Bulaj)
Toxin Structure and Function: What Does Structural Genomics Have To Offer?
(R.S. Norton)
The Sites by which Animal Toxins Bind to their Targets Involve Two
Components: A Clue for Selectivity, Evolution and Design of Proteins? (A.
Ménez, D. Servent and S. Gasparini)
Scorpion Genes and Peptides Specific for Potassium Channels:
Structure,Function and Evolution (L.D. Possani, E. Merino, M. Corona and B.
Becerril)
Scorpion Toxins Differentiating among Neuronal Sodium Channel Subtypes:
Nature's Guide for Design of Selective Drugs (D. Gordon, N. Gilles, D.
Bertrand, J. Molgó, G.M. Nicholson, M.P. Sauviat, E. Benoit, I. Shichor, I.
Lotan, M. Gurevitz, R.G. Kallen and S.H. Heinemann)
Diversification of Toxic Sites on a Conserved Protein Scaffold - a Scorpion
Recipe for Survival (M. Gurevitz, N. Zilberberg, O. Froy, M. Turkov, R.
Wilunsky, I. Karbat, J. Anglister, B. Shaanan, M. Pelhate, M.E. Adams, N.
Gilles, D. Gordon)
Methodological Approaches to the Study of Ion Channels Using Peptide
Toxins: Proposed Comprehensive Guidelines (M. De Waard, J.-M. Sabatier and
H. Rochat)
Toxins as Probes for Structure and Specificity of Synaptic Target Proteins
(P. Taylor, B. Molles, S. Malany and H. Osaka)
Allosteric and Steric interactions of Polyamines and Polyamine-containing
Toxins with Nicotinic Acetylcholine Receptors (T.J. Brier, I.R. Mellor and
P.N.R. Usherwood)
Anabaseine as a Molecular Model for Design of a7 Nicotinic Receptor Agonist
Drugs (W.R. Kem)
Understanding the Structure-Function Relationship of Snake Venom
Cardiotoxins (T.K.S. Kumar, S. Srisailam, R.R. Vethanayagam and C. Yu)
Structure and Function of Disintegrins and C-lectins: Viper Venom Proteins
Modulating Cell Adhesion (S. Niewiarowski, C. Marcinkiewicz, I.
Wierzbicka-Patynowski, M.A. McLane and J.J. Calvete)
Prothrombin Activators from Snake Venoms (R.M. Kini, J.S. Joseph and V.S.
Rao)
C-type Lectins from Snake Venoms: New Tools for Research in Thrombosis and
Haemostasis (A. Wisner, M. Leduc and C. Bon)
Toxins Leading to Medicines (A.L. Harvey)
IV EVOLUTION OF ANIMAL TOXINS
Accelerated and Regional Evolution of Snake Venom Gland Isozymes (M. Ohno,
T. Ogawa, N. Oda-Ueda, T. Chijiwa and S. Hattori)
Functional Diversification of Animal Toxins by Adaptive Evolution (D.
Kordis, I. Kriûaj and F. Gubenëek)
V FROM VENOMS TO TREATMENT
The Venomous Function (M. Goyffon)
Are Inhibitors of Metalloproteinases, Phospholipases A2 and Myotoxins
Members of the Innate System? (J. Perales and G.B. Domont)
The Treatment of Snake Bites: Analysis of Requirements and Assessment of
Therapeutic Efficacy in Tropical Africa (J.-P. Chippaux)
Preface
I TOXINS FROM MICROORGANISMS
Bacterial Toxins with Metalloprotease Activity (O. Rossetto and C.
Montecucco)
The Cholesterol-dependent Cytolysins: Current Perspectives on Membrane
Assembly and Insertion (E. Hotze and R.K. Tweten)
Toxin-producing Dinoflagellates (M.J. Holmes and R. Lewis)
Involvement of Na+ in the Actions of Ciguatoxins and Brevetoxins that
Stimulate Neurotransmitter Release and Affect Synaptic Transmission (J.
Molgó and E. Benoit)
II ANIMAL TOXINS AND NEW METHODOLOGIES
Role of Discovery Science in Toxicology: Examples in Venom Proteomics (J.W.
Fox, J.D. Shannon, B. Stefansson, A.S. Kamiguti, R.D.G. Theakston, S.M.T.
Serrano, A.C.M. Camargo and N. Sherman)
Proteomics of Venom Peptides (R. Stocklin and P. Favreau)
High-resolution NMR of Venom Toxins in Nanomolar Amounts (M. Delepierre)
III ANIMAL TOXINS: FROM FUNDAMENTAL STUDIES TO DRUGS?
Cone Snails and Conotoxins Evolving Sophisticated Neuropharmacology (B.M.
Olivera, J.S. Imperial and G Bulaj)
Toxin Structure and Function: What Does Structural Genomics Have To Offer?
(R.S. Norton)
The Sites by which Animal Toxins Bind to their Targets Involve Two
Components: A Clue for Selectivity, Evolution and Design of Proteins? (A.
Ménez, D. Servent and S. Gasparini)
Scorpion Genes and Peptides Specific for Potassium Channels:
Structure,Function and Evolution (L.D. Possani, E. Merino, M. Corona and B.
Becerril)
Scorpion Toxins Differentiating among Neuronal Sodium Channel Subtypes:
Nature's Guide for Design of Selective Drugs (D. Gordon, N. Gilles, D.
Bertrand, J. Molgó, G.M. Nicholson, M.P. Sauviat, E. Benoit, I. Shichor, I.
Lotan, M. Gurevitz, R.G. Kallen and S.H. Heinemann)
Diversification of Toxic Sites on a Conserved Protein Scaffold - a Scorpion
Recipe for Survival (M. Gurevitz, N. Zilberberg, O. Froy, M. Turkov, R.
Wilunsky, I. Karbat, J. Anglister, B. Shaanan, M. Pelhate, M.E. Adams, N.
Gilles, D. Gordon)
Methodological Approaches to the Study of Ion Channels Using Peptide
Toxins: Proposed Comprehensive Guidelines (M. De Waard, J.-M. Sabatier and
H. Rochat)
Toxins as Probes for Structure and Specificity of Synaptic Target Proteins
(P. Taylor, B. Molles, S. Malany and H. Osaka)
Allosteric and Steric interactions of Polyamines and Polyamine-containing
Toxins with Nicotinic Acetylcholine Receptors (T.J. Brier, I.R. Mellor and
P.N.R. Usherwood)
Anabaseine as a Molecular Model for Design of a7 Nicotinic Receptor Agonist
Drugs (W.R. Kem)
Understanding the Structure-Function Relationship of Snake Venom
Cardiotoxins (T.K.S. Kumar, S. Srisailam, R.R. Vethanayagam and C. Yu)
Structure and Function of Disintegrins and C-lectins: Viper Venom Proteins
Modulating Cell Adhesion (S. Niewiarowski, C. Marcinkiewicz, I.
Wierzbicka-Patynowski, M.A. McLane and J.J. Calvete)
Prothrombin Activators from Snake Venoms (R.M. Kini, J.S. Joseph and V.S.
Rao)
C-type Lectins from Snake Venoms: New Tools for Research in Thrombosis and
Haemostasis (A. Wisner, M. Leduc and C. Bon)
Toxins Leading to Medicines (A.L. Harvey)
IV EVOLUTION OF ANIMAL TOXINS
Accelerated and Regional Evolution of Snake Venom Gland Isozymes (M. Ohno,
T. Ogawa, N. Oda-Ueda, T. Chijiwa and S. Hattori)
Functional Diversification of Animal Toxins by Adaptive Evolution (D.
Kordis, I. Kriûaj and F. Gubenëek)
V FROM VENOMS TO TREATMENT
The Venomous Function (M. Goyffon)
Are Inhibitors of Metalloproteinases, Phospholipases A2 and Myotoxins
Members of the Innate System? (J. Perales and G.B. Domont)
The Treatment of Snake Bites: Analysis of Requirements and Assessment of
Therapeutic Efficacy in Tropical Africa (J.-P. Chippaux)
"...useful not only to those in the field of toxinology, but also to any interested in dramatic examples of the applications and promise of modern techniques of molecular biology to medicine in general." ( Veterinary and Human Toxicology , Vol. 44, No. 6, December 2002)
"...insightful and informative reviews...much to ponder here..." (Chemistry & Industry, (3 March 2003)
"...insightful and informative reviews...much to ponder here..." (Chemistry & Industry, (3 March 2003)