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The petroleum supply chain (PSC) is a sequence of activities that source, transform and deliver petroleum products to end consumers. Understanding the internal drivers of petroleum supply chain disruptions could provide a clue to finding lasting solution to the perennial incidence of petroleum product shortages and exorbitant prices of petroleum products in Cameroon. This paper takes a study of the fundamental principles that shapes petroleum supply chain in Cameroon. This study takes another look at petroleum supply chain risks in Cameroon's oil industries by identifying the drivers of risks that affects the petroleum supply chain and determining mitigation strategies. In order to achieve these objectives of the study and to address the problems, data was collected through the exploitation of secondary and primary sources of information. Results shows that in as much as Cameroon is considered as the most mineralised nation in the sub- Saharan Africa, there still exists shortagesof petroleum products in the country and high prices in relation to the petroleum products.