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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Peutz Jeghers syndrome, also known as hereditary intestinal polyposis syndrome, is an autosomal dominant genetic disease characterized by the development of benign hamartomatous polyps in the gastrointestinal tract and hyperpigmented macules on the lips and oral mucosa. Peutz-Jegher syndrome has a prevalence of approximately 1 in 25,000 to 300,000 births.