Andere Kunden interessierten sich auch für
![Identificazione di coloranti naturali in tessuti copti con HPLC-DAD-MS]( "Identificazione di coloranti naturali in tessuti copti con HPLC-DAD-MS")
Identificazione di coloranti naturali in tessuti copti con HPLC-DAD-MS42,99 €![Cocaine and benzoylecgonine determination using HPLC and SWV methods]( "Cocaine and benzoylecgonine determination using HPLC and SWV methods")
Cocaine and benzoylecgonine determination using HPLC and SWV methods32,99 €![HPLC Determination of Sulphacetamide Sodium & Prednisolone Acetate]( "HPLC Determination of Sulphacetamide Sodium & Prednisolone Acetate")
HPLC Determination of Sulphacetamide Sodium & Prednisolone Acetate32,99 €![New Analytical Methods for the Determination of Pesticide Residues]( "New Analytical Methods for the Determination of Pesticide Residues")
New Analytical Methods for the Determination of Pesticide Residues46,99 €![Nitrate Determination In Environmental Matrices By Hplc]( "Nitrate Determination In Environmental Matrices By Hplc")
Nitrate Determination In Environmental Matrices By Hplc30,99 €![HPLC Method Development and Validation in Pharmaceutical Analysis]( "HPLC Method Development and Validation in Pharmaceutical Analysis")
HPLC Method Development and Validation in Pharmaceutical Analysis51,99 €![Determination of Captopril in some Pharmaceutical products]( "Determination of Captopril in some Pharmaceutical products")
Determination of Captopril in some Pharmaceutical products23,99 €
A stability indicating RP-HPLC method was developed and validated for the determination of Gemifloxacin in tablet formulation. The drug was subjected to forced degradation study in terms of acidic, thermal, oxidative, photo and basic stresses. Degradation products produced as a result of stress testing were successfully separated through C18 column (250 x 4.6 mm, 5 m) using ammonium acetate buffer (pH 2.7; 0.05 M) and acetonitrile (70:30, v/v) as a mobile phase at a flow rate of 0.7 mL/min. The diode array detection was performed at 272 nm. The method was linear over the concentration range of 0.256-128 µg/mL with correlation coefficient equal to 0.9990. The LOD and LOQ were 10 ng/mL and 30 ng/mL respectively. The proposed method was validated according to ICH guidelines. The method showed adequate separation of Gemifloxacin from its stress induced degradation products and excipients with resolution greater than 1.5 within 11 minutes. The method is therefore considered as stability indicating, rapid and suitable for the chromatographic purity and assay determination of Gemifloxacin not only in routine quality control analysis but also for stability studies.