Pharmaceutical Formulation Development of Peptides and Proteins

Herausgeber: Hovgaard, Lars; de Weert, Marco van; Frokjaer, Sven

• Gebundenes Buch

Produktbeschreibung

Rapid advances in recombinant DNA technology and the increasing availability of peptides and proteins with therapeutic potential pose a challenge for pharmaceutical scientists who have to formulate these compounds as drug products. This book focuses on general pharmaceutical developmental aspects of peptides and proteins. The general principles of production, purification, degradation mechanisms, and analysis are discussed. Several chapters discuss the formulation design of peptides and proteins, including protein modification and alternative administration strategies. This second edition also includes chapters on the immunogenicity of protein pharmaceuticals and the biosimulation of pharmacokinetics and pharmacodynamics.

Produktdetails

• Verlag: Taylor and Francis
• 2nd edition
• Seitenzahl: 392
• Erscheinungstermin: 14. November 2012
• Englisch
• Abmessung: 234mm x 157mm x 23mm
• Gewicht: 703g
• ISBN-13: 9781439853887
• ISBN-10: 1439853886
• Artikelnr.: 32958034

Autorenporträt

Lars Rovgaard is Principal Scientist for NovoNordisk A/S and a Professor at Copenhagen University, Denmark. Sven Frokjaer is Dean of the Pharmaceutical Sciences Faculty at the University of Copenhagen Denmark. Marco van de Weert is an Associate Professor of Pharmaceutics and Analytical Chemistry at the University of Copenhagen.

Inhaltsangabe

Peptide Synthesis. Protein Expression. Protein Purification.
Characterization of Therapeutic Peptides and Proteins. Chemical Pathways of
Peptide and Protein Degradation. Physical Instability of Peptides and
Proteins. Peptide and Protein Derivatives. Peptides and Proteins as
Parenteral Solutions. Peptides and Proteins as Parenteral Suspensions.
Rational Design of Solid Protein Formulations. Peptide and Protein Drug
Delivery Systems for Nonparenteral Routes of Administration. Immunogenicity
of Therapeutic Proteins. Biosimulation of Peptides and Proteins.
Registration of Peptides and Proteins. Index.