Pharmacogenomics is the process of analyzing patients genes to predict the onset of adverse reactions or forecast the effectiveness of therapeutic drugs. This useful text is written to discuss both the theory and the clinical application of the principles of pharmacogenomics. Current research has clearly established that a range of treatments may be greatly improved through genetic profiling of individual patients before certain therapies begin. Aimed at clinicians, pharmacologists, and clinical laboratory professionals this book discusses the important role of laboratory tests in the practice…mehr
Pharmacogenomics is the process of analyzing patients genes to predict the onset of adverse reactions or forecast the effectiveness of therapeutic drugs. This useful text is written to discuss both the theory and the clinical application of the principles of pharmacogenomics. Current research has clearly established that a range of treatments may be greatly improved through genetic profiling of individual patients before certain therapies begin. Aimed at clinicians, pharmacologists, and clinical laboratory professionals this book discusses the important role of laboratory tests in the practice of personalized medicine. An important new book, Pharmacogenomics in Clinical Therapeutics serves as a guide to the basic principles of pharmacogenomics in a range of common therapeutic areas and as the basis of the personalized medicine of the future.
Amitava Dasgupta, Ph.D, DABCC, FACB, Professor of Pathology and Laboratory Medicine, University of Texas Health Sciences Center at Houston, Houston, TX. Loralie J. Langman, Ph.D, DABCC, FACB, Associate Professor of Laboratory Medicine, Mayo Clinic, Rochester, MN.
Inhaltsangabe
List of Contributors vii Preface ix 1 Pharmacogenomics Principles: Introduction to Personalized Medicine 1 Parvaz Madadi PhD and Gideon Koren MD 2 Traditional Therapeutic Drug Monitoring and Pharmacogenomics: Are They Complementary? 15 Christine L.H. Snozek PhD Loralie J. Langman PhD and Amitava Dasgupta Ph.D 3 Pharmacogenomics Aspect of Warfarin Therapy 26 Matthew D. Krasowski MD PhD 4 Pharmacogenetics and Cancer Chemotherapy 39 Christine L.H. Snozek 5 Pharmacogenomic Considerations in Anesthesia and Pain Management 53 Christine M. Formea PharmD and Wayne T. Nicholson MD PharmD 6 Pharmacogenomics of Immunosuppressants 70 Nicolas Picard PharmD PhD and Pierre Marquet MD PhD 7 Pharmacogenomics of Cardiovascular Drugs 98 Linnea M. Baudhuin PhD 8 Pharmacogenomic Aspects of Antiretroviral Therapy 127 Natella Y. Rakhmanina MD PhD and John N. van den Anker MD PhD 9 Pharmacogenetics of Psychoactive Drugs 144 Jorge L. Sepulveda MD PhD 10 Pharmacogenomic Aspects of Adverse Drug-Drug Interactions 176 Loralie J. Langman PhD and Christine L.H. Snozek PhD 11 Microarray Technology and Other Methods in Pharmacogenomics Testing 185 Jorge L. Sepulveda MD PhD 12 Pharmacogenetic Testing in the Clinical Laboratory Environment 201 Mark P. Borgman PhD and Mark W. Linder PhD Index 225
List of Contributors vii Preface ix 1 Pharmacogenomics Principles: Introduction to Personalized Medicine 1 Parvaz Madadi PhD and Gideon Koren MD 2 Traditional Therapeutic Drug Monitoring and Pharmacogenomics: Are They Complementary? 15 Christine L.H. Snozek PhD Loralie J. Langman PhD and Amitava Dasgupta Ph.D 3 Pharmacogenomics Aspect of Warfarin Therapy 26 Matthew D. Krasowski MD PhD 4 Pharmacogenetics and Cancer Chemotherapy 39 Christine L.H. Snozek 5 Pharmacogenomic Considerations in Anesthesia and Pain Management 53 Christine M. Formea PharmD and Wayne T. Nicholson MD PharmD 6 Pharmacogenomics of Immunosuppressants 70 Nicolas Picard PharmD PhD and Pierre Marquet MD PhD 7 Pharmacogenomics of Cardiovascular Drugs 98 Linnea M. Baudhuin PhD 8 Pharmacogenomic Aspects of Antiretroviral Therapy 127 Natella Y. Rakhmanina MD PhD and John N. van den Anker MD PhD 9 Pharmacogenetics of Psychoactive Drugs 144 Jorge L. Sepulveda MD PhD 10 Pharmacogenomic Aspects of Adverse Drug-Drug Interactions 176 Loralie J. Langman PhD and Christine L.H. Snozek PhD 11 Microarray Technology and Other Methods in Pharmacogenomics Testing 185 Jorge L. Sepulveda MD PhD 12 Pharmacogenetic Testing in the Clinical Laboratory Environment 201 Mark P. Borgman PhD and Mark W. Linder PhD Index 225
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