Muhammad Usman, Mahmood Ahmad, Asadullah Madni

PHARMACOKINETICS AND BIOAVAILABILITY OF SILYMARIN

IN-VIVO KINETICS OF SILYMARIN (MILK THISTLE); A HEPATOPROTECTIVE AGENT

• Broschiertes Buch

Produktbeschreibung

Silymarin is a purified extract from milk thistle (Silybum marianun (L.) Gaertn), composed of a mixture of isomeric flavonolignans: silybin (its main, active component), isosilybin, silydianin and silychristin. This extract has been empirically used as a remedy for almost 2000 years, and remains being used as a medicine for many types of acute and chronic liver diseases. Despite its routinely clinical use as hepatoprotectant, the mechanisms underlying its beneficial effects remain largely unknown. The purpose of this study was to investigate the pharmacokinetics and bioaequivalence of two brands of Silymarin tablets in healthy male volunteers in local population. Pharmacokinetic parameters were calculated by non- compartmental method using Kinetica® PK/PD version 4.4 and MS Excel Windows professional XP. Maximum concentration of Silymarin in plasma (Cmax), time to these peak plasma concentrations (Tmax) and other bioparameters (AUC0- , AUMC0- , t1/2, Ke, MRT, Vd and ClT) were determined.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 136
• Erscheinungstermin: 20. Januar 2011
• Englisch
• Abmessung: 220mm x 150mm x 9mm
• Gewicht: 221g
• ISBN-13: 9783844300048
• ISBN-10: 384430004X
• Artikelnr.: 32761583

Autorenporträt

The author Dr.Muhammad Usman did M.Sc, M.Phil and PhD in Hematology. He is recently working as Associate Professor of Hematology in Baqai Medical University, Karachi, Pakistan. He is also serving Muhammadi Institute of Hematology as Director and consultant Lab hematologist. He has several international publication in international journal.