Pharmacology's successful approach emphasises the mechanisms by which drugs act and relates these to the overall pharmacological effects and clinical uses.
In doing so it sets out for the reader a clear route from a molecular understanding of receptors and drug actions, to the therapeutic uses of the most important groups of drugs.
An especially well written textbook - it is regularly cited by students as the best textbook they have used.
Now with access to full text online plus many other extras - posted on studentconsult.com access is via unique pin number in front of book!
Presented in full colour, with a new page format and design, the Fifth Edition has been fully updated, incorporating significant new information published in the last few years while dated or obsolete material has been removed.
New agents are fully discussed as well as extensions of basic knowledge which presage further drug development.
Features
This book concentrates on explaining the mechanisms by which drugs act and relates these to their overall pharmacological effects and clinical uses. Clinical application summary boxes throughout reflect the book's increased emphasis on aspects of clinical pharmacology and the clinical use of drugs.
An exceptionally well-written textbook for a major subject in every medical curriculum and also used for a large range of other science/health related courses.
The clinical emphasis is appropriate for the changes in medical teaching providing the student with the necessary overview on how a class of drugs will be used in a clinical situation. Clinical application summary boxes throughout reflect the book's increased emphasis on aspects of clinical pharmacology and the clinical use of drugs.
Puts pharmacology in the perspective of the other science subjects, especially physiology and biochemistry.
Most chapters have brief summaries of relevant physiological and biochemical processes at the beginning to form a basis for the subsequent treatment of pharmacological actions.
"Key points boxes" included in each chapter highlighting all the main facts and ideas.
Appendix lists the most important pharmacological agents divided into those of primary and secondary interest.
Annotated reference and further reading lists are included with emphasis on recent reviews and papers covering significant new advances.
What's New
Page size increased to a larger format to allow enhanced presentation of text features and a more open layout
In full colour throughout with all the line diagrams now in full colour to enhance presentation and understanding of their content.
Chapter overviews introduced to the start of all chapters to help the reader
New 'small print' sections included in many chapters. These contain mainly complex, sometimes speculative, material, which can be skipped by the reader in a hurry without losing the main thread, but will be of interest to readers wishing to go into greater depth.
A new introductory chapter on What is Pharmacology?
New chapters on cellular pharmacology - Excitation, contraction and secretion and Cell proliferation and apoptosis - which describe the cellular mechanisms that are affected by many important drugs described in later parts of the book.
A revision and re-organisation of the chemotherapy section which is now called Drugs used in the treatment of infections and cancer .
One new chapter in the final section on Drug discovery looks at the rapidly changing processes involved which are driven by advances in molecular biology. It contains a brief account of the regulatory controls involved.
Aus dem Inhalt:
SECTION ONE: GENERAL PRINCIPLES
1. What is pharmacology
2. How drugs act: general principles
3. How drugs act: molecular aspects
4. Cellular mechanisms: excitation, contraction and secretion
5. Cellular mechanisms: cell proliferation and apoptosis
6. Method and measurement in pharmacology
7. Absorption and distribution of drugs
8. Drug elimination and pharmacokinetics
SECTION TWO CHEMICAL MEDIATORS
9. Chemical mediators and the autonomic nervous system
10. Cholinergic transmission
11. Noradrenergic transmission
12. Other peripheral mediators: 5-hydroxytryptamine and purines
13. Peptides and proteins as mediators
14. Nitric oxide
15. Local hormones, inflammation and immune reactions
16. Anti-inflammatory and immunosuppressant drugs
SECTION THREE: DRUGS AFFECTING MAJOR ORGAN SYSTEMS
17. The heart
18. The vascular system
19. Atherosclerosis and lipoprotein metabolism
20. Haemostasis and thrombosis
21. The haemopoietic system
22. The respiratory system
23. The kidney
24. The gastrointestinal tract
25. The endocrine pancreas and the control of blood glucose
26. Obesity
27. The pituitary and adrenal cortex
28. The thyroid
29. The reproductive system
30. Bone metabolism
SECTION FOUR: THE NERVOUS SYSTEM
31. Chemical transmission and drug action in the central nervous system
32. Amino acid transmitters
33. Other transmitters and modulators
34. Neurodegenerative disorders
35. General anaesthetic agents
36. Anxiolytic and hypnotic drugs
37. Antipsychotic drugs
38. Drugs used in affective disorders
39. Antiepileptic drugs
40. Analgesic drugs
41. Central nervous system stimulants and psychotomimetic drugs
42. Drug dependence and drug abuse
43. Local anaesthetics
SECTION FIVE: DRUGS USED IN THE TREATMENT OF INFECTIONS AND CANCER
44. Basic principles of chemotherapy
45. Antibacterial drugs
46. Antiviral drugs
47. Antifungal drugs
48. Antiprotozoal drugs
49. Anthelminthic drugs
50. Cancer chemotherapy
SECTION SIX: SPECIAL TOPICS
51. Individual variation and drug interaction
52. Harmful effects of drugs
53. Gene therapy
54. Drug discovery and development.
Appendix
Index
In doing so it sets out for the reader a clear route from a molecular understanding of receptors and drug actions, to the therapeutic uses of the most important groups of drugs.
An especially well written textbook - it is regularly cited by students as the best textbook they have used.
Now with access to full text online plus many other extras - posted on studentconsult.com access is via unique pin number in front of book!
Presented in full colour, with a new page format and design, the Fifth Edition has been fully updated, incorporating significant new information published in the last few years while dated or obsolete material has been removed.
New agents are fully discussed as well as extensions of basic knowledge which presage further drug development.
Features
This book concentrates on explaining the mechanisms by which drugs act and relates these to their overall pharmacological effects and clinical uses. Clinical application summary boxes throughout reflect the book's increased emphasis on aspects of clinical pharmacology and the clinical use of drugs.
An exceptionally well-written textbook for a major subject in every medical curriculum and also used for a large range of other science/health related courses.
The clinical emphasis is appropriate for the changes in medical teaching providing the student with the necessary overview on how a class of drugs will be used in a clinical situation. Clinical application summary boxes throughout reflect the book's increased emphasis on aspects of clinical pharmacology and the clinical use of drugs.
Puts pharmacology in the perspective of the other science subjects, especially physiology and biochemistry.
Most chapters have brief summaries of relevant physiological and biochemical processes at the beginning to form a basis for the subsequent treatment of pharmacological actions.
"Key points boxes" included in each chapter highlighting all the main facts and ideas.
Appendix lists the most important pharmacological agents divided into those of primary and secondary interest.
Annotated reference and further reading lists are included with emphasis on recent reviews and papers covering significant new advances.
What's New
Page size increased to a larger format to allow enhanced presentation of text features and a more open layout
In full colour throughout with all the line diagrams now in full colour to enhance presentation and understanding of their content.
Chapter overviews introduced to the start of all chapters to help the reader
New 'small print' sections included in many chapters. These contain mainly complex, sometimes speculative, material, which can be skipped by the reader in a hurry without losing the main thread, but will be of interest to readers wishing to go into greater depth.
A new introductory chapter on What is Pharmacology?
New chapters on cellular pharmacology - Excitation, contraction and secretion and Cell proliferation and apoptosis - which describe the cellular mechanisms that are affected by many important drugs described in later parts of the book.
A revision and re-organisation of the chemotherapy section which is now called Drugs used in the treatment of infections and cancer .
One new chapter in the final section on Drug discovery looks at the rapidly changing processes involved which are driven by advances in molecular biology. It contains a brief account of the regulatory controls involved.
Aus dem Inhalt:
SECTION ONE: GENERAL PRINCIPLES
1. What is pharmacology
2. How drugs act: general principles
3. How drugs act: molecular aspects
4. Cellular mechanisms: excitation, contraction and secretion
5. Cellular mechanisms: cell proliferation and apoptosis
6. Method and measurement in pharmacology
7. Absorption and distribution of drugs
8. Drug elimination and pharmacokinetics
SECTION TWO CHEMICAL MEDIATORS
9. Chemical mediators and the autonomic nervous system
10. Cholinergic transmission
11. Noradrenergic transmission
12. Other peripheral mediators: 5-hydroxytryptamine and purines
13. Peptides and proteins as mediators
14. Nitric oxide
15. Local hormones, inflammation and immune reactions
16. Anti-inflammatory and immunosuppressant drugs
SECTION THREE: DRUGS AFFECTING MAJOR ORGAN SYSTEMS
17. The heart
18. The vascular system
19. Atherosclerosis and lipoprotein metabolism
20. Haemostasis and thrombosis
21. The haemopoietic system
22. The respiratory system
23. The kidney
24. The gastrointestinal tract
25. The endocrine pancreas and the control of blood glucose
26. Obesity
27. The pituitary and adrenal cortex
28. The thyroid
29. The reproductive system
30. Bone metabolism
SECTION FOUR: THE NERVOUS SYSTEM
31. Chemical transmission and drug action in the central nervous system
32. Amino acid transmitters
33. Other transmitters and modulators
34. Neurodegenerative disorders
35. General anaesthetic agents
36. Anxiolytic and hypnotic drugs
37. Antipsychotic drugs
38. Drugs used in affective disorders
39. Antiepileptic drugs
40. Analgesic drugs
41. Central nervous system stimulants and psychotomimetic drugs
42. Drug dependence and drug abuse
43. Local anaesthetics
SECTION FIVE: DRUGS USED IN THE TREATMENT OF INFECTIONS AND CANCER
44. Basic principles of chemotherapy
45. Antibacterial drugs
46. Antiviral drugs
47. Antifungal drugs
48. Antiprotozoal drugs
49. Anthelminthic drugs
50. Cancer chemotherapy
SECTION SIX: SPECIAL TOPICS
51. Individual variation and drug interaction
52. Harmful effects of drugs
53. Gene therapy
54. Drug discovery and development.
Appendix
Index