Oral and Maxillofacial practice involves use of many therapeutics to facilitate the treatment or promote healing. Pharmacotherapy in Oral diseases is of utmost importance as it enables general practitioners and other specialties in early diagnosis and apt treatment of the lesions. This is because many systemic diseases manifest first in the oral cavity, thus aiding in a good prognosis. A careful evaluation of these drugs as reported in literature, a detailed knowledge about their side effects, interactions with other chemicals, and how any alterations in the patient's physiology enhance or suppress the mechanism of action of these drugs is needed before their use or prescription. It is always prudent to remember that no medicine is without side effects and the benefits of using them should be weighed against the risks involved.