Christian Schudt / Gordon Dent / Klaus F. Rabe (Volume ed.)

Phosphodiesterase Inhibitors

Herausgeber: Page, Clive

• Gebundenes Buch

Produktbeschreibung

Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting. Key Features* Utilizes actual testing and research of new PDE inhibitors* Valuable for researchers and students alike

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Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.

Produktdetails

• Verlag: Elsevier Science
• Seitenzahl: 228
• Erscheinungstermin: 27. August 1996
• Englisch
• Abmessung: 260mm x 194mm x 18mm
• Gewicht: 676g
• ISBN-13: 9780122107207
• ISBN-10: 0122107209
• Artikelnr.: 21201786

Inhaltsangabe

K.M. Ferguson and K. Loughney, Identification and Quantification of PDE
Isoenzymes and Subtypes by Molecular Biological Methods.
H. Tenor and C. Schudt, Analysis of PDE Isoenzyme Profiles in Cells and
Tissues by Pharmacological Methods.
K.F. Rabe, Effects of Theophylline and Nonselective Xanthine Derivatives on
PDE Isoenzymes and Cellular Function.
R.K. Sharma, Interaction of PDE I Inhibitors with Isoenzymes and Cell
Functions.
R. Fischmeister, EHNA as an Inhibitor of PDE II.
V.C. Manganiello, PDE II Inhibitors as Therapeutic Agents.
M.A. Giembycz, Interaction of PDE IV Inhibitors with Enzymes and Cell
Functions and their Therapeutic Potential.
P.J. Silver, Inhibition of PDE Isoenzymes and Cell Function by Selective
PDE V Inhibitors.
J.D. Corbin, Design and Synthesis of Xanthines and Cyclic GMP Analogues as
Potent Inhibitors of PDE V and PDE I.
A. Hatzelmann, Enzymatic and Functional Inhibition of Dual-Selective
Inhibitors.
R. Alvarez, Subtype Selectivity, Inhibition of Cell Function and
Therapeutic Potential of RS 25344.
J.E. Souness, Characterization of Different States of PDE IV by Rolipram
and RP 73401.
T.J. Torphy, Functional Significance of Two Sites for Inhibitors at PDE IV.
Subject Index.