Phospholipase A2 inhibitors as anti-inflamatory molecules

Phospholipase A2 inhibitors as anti-inflamatory molecules

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Secretory phospholipase A2 is a crucial regulatory enzyme in the initiation of any inflammatory reactions there by producing various pro-inflammatory lipid mediators and reactive oxygen species. Elevateted level of sPLA2 is reported in all pathophysiological conditions. During the healing process this enzyme should be down regulated, other wise the defensive inflammatory reactions become potentially harmful and ends up in various chronic inflammatory disorders which are life threatening. The reactive oxygen species produced during injury and infection that inturn activates PLA2 enzyme by that ...