Andere Kunden interessierten sich auch für
![Antimicrobial Photodynamic Therapy]( "Antimicrobial Photodynamic Therapy")
Antimicrobial Photodynamic Therapy171,99 €![]()
"Mitocans" - uma estratégia alternativa para o tratamento do câncer.32,99 €![Dokumente zur Geschichte der Pharmazie]( "Dokumente zur Geschichte der Pharmazie")
Dokumente zur Geschichte der Pharmazie28,00 €![Pharmacogenetics of Depression]( "Pharmacogenetics of Depression")
Pharmacogenetics of Depression44,99 €![Herbal Drugs]( "Herbal Drugs")
Herbal Drugs38,99 €![Anti-inflammatory Activity of Diospyros variegata Kruz]( "Anti-inflammatory Activity of Diospyros variegata Kruz")
Anti-inflammatory Activity of Diospyros variegata Kruz32,99 €![Proteomics Of Scorpion Venom]( "Proteomics Of Scorpion Venom")
Proteomics Of Scorpion Venom32,99 €
This book describes the design, physicochemical
characterisation and clinical evaluation of
bioadhesive drug delivery systems for photodynamic
therapy of difficult-to-manage vulval neoplasias and
dysplasias. In photodynamic therapy (PDT), a
combination of visible light and a sensitising drug
causes the destruction of selected cells. ALA is
commonly delivered to the vulva using creams or
solutions, which are covered with an occlusive
dressing to aid retention and enhance drug
absorption. Such dressings are poor at staying in
place at the vulva, where shear forces are high in
mobile patients.
To overcome the problems associated with delivery of
ALA to the vulva, we produced a bioadhesive patch
by a novel laminating procedure. The ALA loading was
38 mg cm-2. Patches were shown to release more ALA
over 6 hours than the proprietary cream. The ALA
concentration in tissue at 2.375 mm was an order of
magnitude greater than that found to be cytotoxic to
HeLa cells. Clinically, the patch was used in
successful PDT of vulval intraepithelial neoplasia,
lichen sclerosus, squamous hyperplasia, Paget s
disease and vulvodynia.
characterisation and clinical evaluation of
bioadhesive drug delivery systems for photodynamic
therapy of difficult-to-manage vulval neoplasias and
dysplasias. In photodynamic therapy (PDT), a
combination of visible light and a sensitising drug
causes the destruction of selected cells. ALA is
commonly delivered to the vulva using creams or
solutions, which are covered with an occlusive
dressing to aid retention and enhance drug
absorption. Such dressings are poor at staying in
place at the vulva, where shear forces are high in
mobile patients.
To overcome the problems associated with delivery of
ALA to the vulva, we produced a bioadhesive patch
by a novel laminating procedure. The ALA loading was
38 mg cm-2. Patches were shown to release more ALA
over 6 hours than the proprietary cream. The ALA
concentration in tissue at 2.375 mm was an order of
magnitude greater than that found to be cytotoxic to
HeLa cells. Clinically, the patch was used in
successful PDT of vulval intraepithelial neoplasia,
lichen sclerosus, squamous hyperplasia, Paget s
disease and vulvodynia.