Hanne Hjorth Tonnesen (ed.)

Photostability of Drugs and Drug Formulations

Herausgeber: Tonnesen, Hanne Hjorth

• Gebundenes Buch

Produktbeschreibung

Covering in vitro and in vivo aspects of drug photoreactivity, this book provides the background necessary for the planning of standardized photochemical stability studies as a part of drug development and formulation work. The second edition of a bestseller, it focuses on standardization of photostability testing of drug substances and products, in vitro photoreactivity screening of drugs, and various aspects of the formulation of photoreactive substances. With chapter authors drawn from an international panel of experts, the second edition has been completely revised and updated to emphasize the significance of information and knowledge on drug photoreactivity in a pharmaceutical context.

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Produktdetails

• Verlag: CRC Press
• Revised
• Seitenzahl: 448
• Erscheinungstermin: 29. Juni 2004
• Englisch
• Abmessung: 240mm x 161mm x 29mm
• Gewicht: 836g
• ISBN-13: 9780415303231
• ISBN-10: 0415303230
• Artikelnr.: 22086676

Autorenporträt

Hanne Hjorth Tønnesen

Inhaltsangabe

Introduction: Photostability Testing of Drugs and Drug Formulations - Why
and How? Photophysical and Photochemical Aspects of Drug Stability.
Standardization of Kinetic Studies of Photodegradation Reactions.
Rationalizing the Photochemistry of Drugs. Technical Requirements and
Equipment for Photostability Testing. Photostability Testing: Design and
Interpretation of Tests on New Drug Substances and Dosage Forms. The
Questions Most Frequently Asked. Inconsistencies and Deficiencies Which
Exist in the Current Official Regulations Concerning the Photolytic
Degradation of Drugs. Benefits and Adverse Effects from the Combination of
Drugs and Light. In Vitro Screening of the Photoreactivity of
Antimalarials. A Test Case. Screening of Dyes, Drugs and Dietary
Supplements for Ocular Phototoxicity. Photochemical and Photophysical
Methods Used in the Study of Drug Photoreactivity. Addressing the Problem
of Light Instability During Formulation Development. Photostability of
Parenteral Products. Photoactivated Drugs and Drug Formulations.
Formulation Approaches for Improving Solubility and its Impact on Drug
Photostability. Appendices.