Physical biochemistry is a branch of biochemistry that deals with the theory, techniques and methodology used to study the physical chemistry of biomolecules. It also deals with the mathematical approaches for the analysis of biochemical reactions and the modeling of biological systems. It provides insight to the structure of macromolecules, and how chemical structure influences physical properties of a biological substance. The entire text has been lucidly presented, orderly arranged and profusely illustrated. A stunning and highly important thing about this work is that the derivation of Michaelis-Menten equation is clearly done. No single biochemistry text derived the equation as clear as I did in this masterpiece, such that even students who are below average in math can easily learn it. The book is titled Physical Biochemistry II, a course offered by HND I students of Science Laboratory Technology, world over. It covers all the topics under the course and more. Students and instructors of biochemistry and related courses will find this novel work immensely useful.