The conference “Physics at the LHC 2010” took place at DESY in Hamburg, Germany, from 7–12 July2010. It was the fifth conference of the PLHC series, which started in Prague in 2003 and continued inVienna (2004), Cracow (2006) and Split (2008). The rich programme covered all fields of LHC physicsand attracted more than 270 participants, demonstrating the vivid interest by both experimentalists andtheorists.