The traditional system of medicine in India. Lantana camara, Family:Verbenaceae has been important coniferous plant in ayurvedic and indigenous medicinal systems. The Clinical trials and animal research support the use of Lantana camara for anti-spasmodic, carminative, anti-tumour, antiinflammatory, anti-malarial, anti-ulcer genic, treatment of emotional stress andtrauma, anti-microbial, insecticidal, fungicidal, asthma. Major biochemicalconstituents of Lantana camara were identified as alkaloids/flavonoids,saponins/tannins, germacrene valencene (principle constituent) and Gamma-gurjunene, verbascoside, martynoside.This paper includes the evidence-based over view of phytochemical and antimicrobial properties of the aerial parts of Lantana camara.