Phytochemical Investigations on Constituents of Medicinal Plants - Fatima, Itrat
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This book describes the phytochemical investigations carried out on two indigenous medicinal plants of Pakistan namely, Isatis costata and Leucas urticifolia. Part A is about the isolation and structure elucidation of five new alkaloids named as costinone A, costinone B, isatinone A, isatinone B and isamide. In addition, five known compounds caffeic acid ester, docosyl caffeate, methyl-2 acetoamidobenzoate, -sitosterol and ursolic acid have also been isolated and characterized for the first time from this species. Compounds costinone A and costinone B inhibited lipoxygenase and…mehr

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Produktbeschreibung
This book describes the phytochemical investigations carried out on two indigenous medicinal plants of Pakistan namely, Isatis costata and Leucas urticifolia. Part A is about the isolation and structure elucidation of five new alkaloids named as costinone A, costinone B, isatinone A, isatinone B and isamide. In addition, five known compounds caffeic acid ester, docosyl caffeate, methyl-2 acetoamidobenzoate, -sitosterol and ursolic acid have also been isolated and characterized for the first time from this species. Compounds costinone A and costinone B inhibited lipoxygenase and butyrylcholinesterase enzymes non-competitively in concentration-dependent fashion with promising inhibitory potentials. Compounds isatinone A and isatinone B showed vital antifungal activity. Part B describes the isolation and structure elucidation of two new compounds named as leucisterol and urticic acid, along with four known compounds named as 2-methoxybenzyl benzoate , 4-hydroxy benzoic acid , -sitosterol and ursolic acid which are reported first time from this species. The compound leucisterol showed potent inhibitory activity against butyrylcholinesterase enzyme.
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Autorenporträt
Dr. Itrat Fatima obtained PhD in 2010 from University of Karachi, Pakistan. She has authored/co-authored over 40 scientific publications and a winner of Research Productivity Awards in 2012 and 2013. Her research interests are the areas of isolation and spectroscopic analysis of new biological active compounds in medicinal plants of Pakistan.