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In the present era, there are rapid advancements in the fields of medical and pharmaceutical sciences.Even though there is a rapid advancement, equally there is emergence of new diseases caused by different microbial organisms.Extensive use of the existing drugs leads to emergence of antibiotic resistance pathogens.There were several reports that the pathogenic bacteria were evolving and becoming resistant to the drugs over the time. Pathogenic organisms cause many infections in human beings such as pulmonary, respiratory, cutaneous, nosocomial and several other communicable infections.Majority of the times, we observe these infections in immune deficient patients who are sensitive and more likely to be affected by these pathogens. Chemically synthesized drugs are very effective against the infectious diseases but, on the other hand, they are found to have many side effects.Therefore, there is a need to look for alternative drugs for the chemical drugs.Plants serve as major sources of potential drugs. They are bio compatible and have no side effects.Plants produce secondary also called as phytochemicals. Calotropis gigantea is one of such plant which possess medicinal properties..