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Osteoporosis has become a global health issue of major concern. It is defined as a condition illustrated by micro-architectural deterioration and low mineral density of bone tissues resulting into enhanced bone fragility and increased risk of fracture. Osteoporosis shows its existence in several forms, with some induced by drugs while others occurring as a chronic progressive disorder associated with aging. Prevalence of osteoporosis can also be attributed to deficiency of calcium and vitamin D and a result of hormonal changes. Medicinal plants have been used traditionally for the management and control of osteoporosis. The present book summarizes the biological effects of the various medicinal plants and theiir phytoconstituents used to maintain the bone health and their associated mechanisms.