Pictet-Spengler Reaction to Indole Based Alkaloids - Chanda, Kaushik
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Indole based alkaloids are well known in the literature for their diverse biological properties. Polysubstituted optically active tetrahydro-beta-carboline derivatives functionalized on C-1 position are the common structural motif in most of the indole based alkaloids as well as highly marketed drugs. The stereoselective Pictet-Spengler reaction is one of the currently most important synthetic techniques used for the preparation of these privileged tetrahydro-beta-carboline scaffolds. To date there are numerous research reports that have been published on the synthesis of the…mehr

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Produktbeschreibung
Indole based alkaloids are well known in the literature for their diverse biological properties. Polysubstituted optically active tetrahydro-beta-carboline derivatives functionalized on C-1 position are the common structural motif in most of the indole based alkaloids as well as highly marketed drugs. The stereoselective Pictet-Spengler reaction is one of the currently most important synthetic techniques used for the preparation of these privileged tetrahydro-beta-carboline scaffolds. To date there are numerous research reports that have been published on the synthesis of the tetrahydro-beta-carboline scaffold both on solid phase as well as in solution phase. Moreover rapid growth has been observed for the enantioselective synthesis of tetrahydro-beta-carboline scaffold using chiral organocatalysts. In this book, efforts have been taken to shed light on the latest information available on different strategies to synthesize tetrahydro-beta-carboline both on solid phase and in solution phase during the last 20 years.
Autorenporträt
Dr Kaushik Chanda is an Assistant Professor in Department of Chemistry, VIT University, Vellore, India. He has published more than 25 international peer-reviewed journal articles and one US patent to his credit. He has delivered invited talks in national and international conferences.