Wan Haslindawani Wan Mahmood, Rapiaah Mustafa, Wan Soriany Wan Mohd Zain

Platelet Alloantibody

The Risk of Multiple Transfusions

• Broschiertes Buch

Produktbeschreibung

The frequency of platelet-specific antibodies in multitransfused patients and their implication in platelet transfusion refractoriness has been a matter of controversy for years. The main reasons are the difficulties encountered in differentiating between HLA- and platelet-specific antibodies and, within platelet-specific antibodies, between auto- or alloantibodies, using the available platelet antiglobulin test. In the recent years, capture assays were developed, using immobilized platelet membrane glycoprotein (GP) carrying the antigens under investigation to avoid using whole platelets. These assays overcome the difficulties in differentiating platelet-reactive antibody mixtures and allow determination of antibody specificity. For the group of highly HLA-immunized patients in need for HLA-matched single donor platelets, however, there are only as many as 25% will have additional platelet-specific alloantibodies. These platelet-specific alloantibodies will prohibit satisfactorytransfusion results if HLA-matched but HPA-incompatible platelets are transfused.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Aufl.
• Seitenzahl: 64
• Englisch
• Abmessung: 220mm
• ISBN-13: 9783846505045
• ISBN-10: 3846505048
• Artikelnr.: 35507140

Autorenporträt

Dr Wan Haslindawani Wan Mahmood,from Malaysiais a Senior Medical Lecturer,with the qualifications inHaematology. She has a working experience for 14years. Her current academic responsibility is inHaematology and Transfusion. Her research interestin Donor Management and Platelet serology. Shepublished 27 academic journals and two academic book