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In current times, one of the most promising innovations in the field of surgical dentistry is the use of platelet-rich fibrin (PRF). Used alone or as an additive with other biomaterials, it accelerates the healing mechanism of the tissue and reduces the inflammation.Platelet-rich fibrin (PRF) has been used in regenerative medicine and dentistry. The usage of PRF has reported significant advantages because it enhances osteoprogenitor cells in the host bone and bone graft. The PRF protocol in oral and maxillofacial surgery was introduced to improve bone healing in implant dentistry and its application in various disciplines of Dentistry.