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The application of PRF in fields of plastic surgery, oral and maxillofacial surgery and implant surgery has demonstrated successful and rapid results in terms of bone regeneration. The field of periodontal therapy has just begun to explore the vast benefits of PRF for management of various types of periodontal defects. Recently various investigators have examined efficacy of PRF for the regeneration of various types of periodontal defects including alveolar ridge preservation and sinus augmentation. Therefore, attempt has been made to provide update literature on present status of PRF in regeneration of various types of periodontal defect and effectiveness of PRF for regeneration of bone during adjunctive implant therapy. In addition, the current evidence for the role of PRF in tissue engineering has been added.