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Diabetic patients are known to have delayed bone and wound healing compared to normal patients. The objective of this study was to improve success rates by employing a minimally invasive implant to decrease the size of the wound and autogenous platelet rich plasma (PRP) to enhance the bone healing. This was a Non-randomized clinical trial employing a split-mouth design consisting of patients selected from the diabetic clinic at the Hospital University Sains Malaysia. Using a one-stage surgical protocol, a total of 28 Mini Drive Lock implants (Intra-lock® USA) implants with lengths of 10, 11.5, 13 and a diameter of 2.0 mm of 2.5 mm were inserted in edentulous and partially edentulous patients.This study showed no significant difference of wound healing when comparing groups of PRP and non-PRP in controlled diabetic patients. The use of minimally invasive implant procedure can help to improve the soft tissue wound healing and bone osseointegration in diabetic patients with or without PRP. In conclusion the wound healing in diabetic patients is highly dependant upon the severity of tissue trauma, therefore emphases on implant placement technique should be considered.