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This issue of Clinics in Chest Medicine, edited by Dr. Michael Niederman, focuses on Pneumonia, with topics including: Inflammation and Pneumonia; The Lung Microbiome's Role in Pneumonia; Biomarkers for the Management of Pneumonia; Influenza and Viral Pneumonia; Guidelines to Manage Community-Acquired Pneumonia (CAP); Vaccines to Prevent CAP; Adjunctive Therapies for CAP; Healthcare Associated Pneumonia; Rapid Diagnostic Methods for Pneumonia; Airway Devices in VAP Pathogenesis and Prevention; Management of VAP; Distinguishing Ventilator-Associated Tracheobronchitis from VAP; Practical Approaches to VAP Prevention; Optimizing Antibiotic Administration for Pneumonia; New Antibiotics for Pneumonia; and Personalized Approach to Pneumonia Management.