The purpose of this paper is to study the effect of political instability on economic growth in CEMAC. To achieve this, we presented the concepts of the study as well as the literature dealing with the link between them. Then we proceeded to the empirical verification of the relationship between political instability and economic growth. A multiple linear regression model allowed us to relate political instability to economic growth. Using ordinary least squares (OLS) panel data over the period 2007-2019, it is found that political instability has a negative and significant influence on economic growth.