Pesticides and its derivatives have found their way into every branch of science. They possess a variety of pharmacological, agrochemical and industrial applications. A lot of pesticide derivatives have insecticidal, anti-viral, anti-bacterial, anti-fungal, anti-microbial, fungicidal and herbicidal properties. The biological and chemical properties of pesticide derivatives are depending on its structure, especially the structural configuration of the substituted groups. Though the structural activity relationship has been established very earlier, there is not much pesticide report exclusively concerning the microbial degradation.Information currently available on the microbial degradation of pesticides is reviewed with particular respect to microorganisms responsible for the biochemical reactions involved, and to the main degradation products identified. This current research study includes the fate of pesticides in soil and the significance of microbial communities in bio-degradation; pesticide effects on soil microorganisms, methods for isolating pesticide degrading microorganisms from the soil environment; biochemical reactions involved in pesticide degradation by microbes...