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High Quality Content by WIKIPEDIA articles! Polydrug use refers to the use of two or more psychoactive drugs in combination to achieve a particular effect. Often called "cross fading", it is usual among problem drug users who have a multi-drug dependence. In many cases one drug is used as a base-primary - or preferred drug, with additional drugs to leaven or compensate for the side effects of the primary drug and make the experience more enjoyable with drug synergy effects, or to supplement for primary drug when supply is low. Poly drug use often carries with it more risk than use of a single…mehr

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High Quality Content by WIKIPEDIA articles! Polydrug use refers to the use of two or more psychoactive drugs in combination to achieve a particular effect. Often called "cross fading", it is usual among problem drug users who have a multi-drug dependence. In many cases one drug is used as a base-primary - or preferred drug, with additional drugs to leaven or compensate for the side effects of the primary drug and make the experience more enjoyable with drug synergy effects, or to supplement for primary drug when supply is low. Poly drug use often carries with it more risk than use of a single drug, due to an increase in side effects, and drug synergy. The potentiating effect of one drug on another is sometimes considerable and here the licit drugs and medicines ? such as alcohol, nicotine and antidepressants ? have to be considered in conjunction with the controlled psychoactive substances. The risk level will depend on the dosage level of both substances.