Polycomb Proteins in Health and Disease - El-Gamal, Randa;Shaalan, Dalia;Said, Muhamad
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Polycomb group (PcG) proteins are well-conserved chromatin factors that repress the transcription of their target genes. They bind to the genome at specific sites and act on chromatin through the regulation of both post-translational histone modifications and higher-order chromatin structure. Aberrant expression of multiple PcG genes are implicated in different types of human cancers. PcGs are considered as novel prognostic markers both in terms of improving diagnosis as well as predicting patient response to treatment. Pharmacological targeting of PcG proteins is emerging as an attractive…mehr

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Produktbeschreibung
Polycomb group (PcG) proteins are well-conserved chromatin factors that repress the transcription of their target genes. They bind to the genome at specific sites and act on chromatin through the regulation of both post-translational histone modifications and higher-order chromatin structure. Aberrant expression of multiple PcG genes are implicated in different types of human cancers. PcGs are considered as novel prognostic markers both in terms of improving diagnosis as well as predicting patient response to treatment. Pharmacological targeting of PcG proteins is emerging as an attractive strategy. In addition, some nutrients can modify the expression of PcG proteins in physiologic and pathologic processes.
Autorenporträt
Randa Ibrahim El-Gamal; assistant lecturer of Medical Biochemistry and Molecular Biology, Mansoura Faculty of Medicine-Egypt.Bachelor of Medicine and General Surgery,2008¿ Mansoura Faculty of Medicine¿Egypt.Master of Medical Biochemistry & Molecular Biology, 2014-Mansoura Faculty of Medicine¿Egypt.