Polyglobulia Vaquez - Bouatay, Amina;Ben sayed, Nesrine;Dardour, Saoussen
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Vaquez polycythemia (PV) is a myeloproliferative neoplasm resulting from clonal expansion of a pluripotent hematopoietic stem cell, causing proliferation of myeloid tissue predominantly in the erythrocyte lineage. It is characterized by an increase in total erythrocyte mass and hemoglobin without excessive stimulation by erythropoietin. Its incidence is low (2 to 3 cases per 100,000 inhabitants/year). The initial presentation is often pauci symptomatic. In some patients the occurrence of a thrombotic event or symptoms related to hyperviscosity syndrome leads to the diagnosis of PV.The…mehr

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Produktbeschreibung
Vaquez polycythemia (PV) is a myeloproliferative neoplasm resulting from clonal expansion of a pluripotent hematopoietic stem cell, causing proliferation of myeloid tissue predominantly in the erythrocyte lineage. It is characterized by an increase in total erythrocyte mass and hemoglobin without excessive stimulation by erythropoietin. Its incidence is low (2 to 3 cases per 100,000 inhabitants/year). The initial presentation is often pauci symptomatic. In some patients the occurrence of a thrombotic event or symptoms related to hyperviscosity syndrome leads to the diagnosis of PV.The discovery of the JAK2 V617F mutation has completely changed the diagnosis of PV and has allowed not only a better understanding of the pathophysiological mechanisms, but also the development of a targeted molecular therapy associated with an efficient molecular monitoring.
Autorenporträt
Pr Bouatay Amina estudou na Faculdade de Farmácia de Monastir na Tunísia. Ingressou na carreira hospitalar universitária como AHU, depois foi professora associada no laboratório de hematologia do Hospital Universitário Farhat Hached em Sousse. Depois, em 2019, foi nomeada Chefe do Departamento do Laboratório de Hematologia do Hospital Universitário de Sahloul Sousse-Tunisia.