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During the drilling of highly permeable, highly fractured and low pressured zones; loss of the drilling fluid as a result of the migration through the drilling formations is known as lost of circulation. The risk of drilling wells in areas known to contain these problematic formations was a key factor in the decisions to approve or cancel exploration and development projects. A wide variety of materials can be added to the drilling fluid to seal off the lost circulation zones. This book is divided into three studies; the first one is the synthetic polymers, the second one explains the lost circulation control property of water-soluble natural polymers and the third one is investigation of water-insoluble natural polymers as lost circulation control agents.