Polymers for Oral Drug Delivery Technologies

Herausgeber: Parambath, Anilkumar

• Broschiertes Buch

Produktbeschreibung

Polymers for Oral Drug Delivery Technologies covers the fundamentals of oral drug delivery and various aspects of polymer technology in oral drug delivery, from classification and synthesis, to applications and regulatory factors. It presents the oral delivery¿of therapeutics for treating a number of diseases, along with the challenges of oral drug administration to assure a predictive and reproducible pharmacokinetic profile of active pharmaceutical ingredients (API). Polymers play an important role to achieve the targeted release profile consistently of an API in vivo by various functionalities like drug protection from gastric juice, fast release and supersaturation or release within a targeted area of the GI tract.

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Produktdetails

• Verlag: Elsevier Science
• Seitenzahl: 854
• Erscheinungstermin: 30. September 2024
• Englisch
• Gewicht: 1000g
• ISBN-13: 9780443137747
• ISBN-10: 0443137749
• Artikelnr.: 69905070

Inhaltsangabe

Section A. Fundamentals of Oral Drug Delivery 1. GI tract environment (e.g.
gastric juice, bile salts, pH, amylases, proteases etc.) 2. GI tract
motility and transport 3. Drug absorption and pre-systemic metabolism and
PK modelling 4. In vitro dissolution and predictive release testing 5.
Principle characteristics and specification of pharmaceutical polymers 6.
Regulatory Aspects of Polymers Used and new polymers for Oral Medication
Section B. Role Polymer Technology in Oral Drug Delivery 7. Classes/types
of polymers used in oral delivery (natural, semi-synthetic, synthetic),
their chemical structure and general functionalities 8. Role of polymers in
Tableting 9. Capsule forming Polymers 10. Dry and wet Granulation 11.
Matrix formers 12. Functional Polymer Coatings (IR, easy to swallow,
enteric etc.) 13. Amorphous systems (e.g. HME, SD) 14. Micro/Nanoparticles
15. Taste masking polymers 16. Polymers in Orally disintegrating tablets
and Orally dissolving films 17. Additive manufacturing (3D printing) 18.
Mucoadhesive forms 19. Gastro-retentive forms 20. Polymer blends and
additives