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The present study investigate the effect of polyphenolic extracts of Prunus domestica red (PDR) and Prunus domestica yellow (PDY) wall nuts on some biochemical parameters in female rats and anti-bacterial in vitro. The work involved the following studies: Analytical study, Acute toxicity, Boody weight, Biochemical studies and Antibacterial study. The final conclusion is that the PDR and PDY extracts are rich in polyphenols. Besides, the polyphenolic compounds non toxic, have affect the hypolipidemic, antioxidant activities and antibacterial.