Population balance modelling of non-native protein aggregation - Grancic, Peter
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A comprehensive modelling methodology for analysis of the kinetics of non-native protein aggregation based on general population balance model within the Extended Lumry-Eyring framework is presented. The population balance model is formulated in terms of key parameters, describing relative importance of (un)folding and aggregation kinetics of a protein in diffusion-driven conditions. Both the analytical and numerical solution provide a detailed insight on the intrinsic aggregation kinetics via time-dependent evolution of a variety of experimentally measurable quantities.

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Produktbeschreibung
A comprehensive modelling methodology for analysis of the kinetics of non-native protein aggregation based on general population balance model within the Extended Lumry-Eyring framework is presented. The population balance model is formulated in terms of key parameters, describing relative importance of (un)folding and aggregation kinetics of a protein in diffusion-driven conditions. Both the analytical and numerical solution provide a detailed insight on the intrinsic aggregation kinetics via time-dependent evolution of a variety of experimentally measurable quantities.
Autorenporträt
Dr. Peter Grancic obtained his PhD in 2009 investigating the non-native protein aggregation at the University of Strathclyde (Glasgow, Scotland). Following a 3 year position at the Chemical Robotics Laboratory (Prague, Czech Republic). Since 2012 he works as a postdoctoral research associate at the Radboud University (Nijmegen, The Netherlands).