Porcine reproductive and respiratory syndrome (PRRS) is a swine disease which appeared simultaneously in Europe (early 1990s) and North America (late 1980s) and continues to be one of the major diseases that affect the swine industry worldwide. PRRS is characterized by respiratory problems, like cough and dyspnea, in growing and finishing pigs and reproductive failure in sows, with late term abortion, stillbirth and increased preweaning mortality. In order to combat this disease, the implementation of control protocols (biosecurity and hygiene, immunization) is necessary together with PRRS eradication measures, including total depopulation and repopulation of the farm or the closing of the holding for at least six months, among others. Authors lead the reader through several aspects of PRRS in order to provide a global approach on control/eradication and prevention of this viruses on pig farms.