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This issue of Critical Care Clinics focuses on Post-intensive Care Syndrome & Chronic Critical Illness, with topics including: Chronic Critical Illness; Chronic Critical Illness and Predicting Outcomes; Persistent Critical Illness; Rehospitalization and Preventing CCI; Measuring Post-Intensive Care Syndrome; Post-Intensive Care Syndrome and teh Role of the ICU Clinician; Frailty and the Association between Long-Term Recovery After ICU; The Role of the Muscles in Post-Intensive Care Syndrome; Intensive Care Nutrition and Post-Intensive Care Recovery; Early mobilization in the ICU to Improve Long Term Recovery; The Use of Sedation in the ICU and Long-Term Outcomes; Cognitive Function after Critical Illness; Anxiety and Depression after ICU; and Family and Support Networks after ICU.