Potassium channels (K + ) are membrane-spanning proteins which serve many important functions and are becoming a hot topic in physiology. K + channels determine or modulate many functions of vascular smooth muscle, endothelial and inflammatory cells, and thus are central to regulation of arterial tone and control of cell proliferation. They are also promising targets for antihypertensive treatments with drugs which open and close specific types of K + channels, making for an active field of research. With their ability to control vascular tone, voltage-gated K + channels play a significant…mehr
Potassium channels (K+) are membrane-spanning proteins which serve many important functions and are becoming a hot topic in physiology. K+ channels determine or modulate many functions of vascular smooth muscle, endothelial and inflammatory cells, and thus are central to regulation of arterial tone and control of cell proliferation. They are also promising targets for antihypertensive treatments with drugs which open and close specific types of K+ channels, making for an active field of research. With their ability to control vascular tone, voltage-gated K+ channels play a significant role in both pulmonary and systemic hypertension as well as in cardiac arrhythmias. This book will highlight the latest discoveries by leading researchers pertaining to the role of K+ channels in the heart and blood vessels in normal physiology and a variety of disease states.
1 Evolution of Potassium Channel Proteins.- 2 Three-Dimensional Structure of the K+ Channel Pore: Basis for Ion Selectivity and Permeability.- 3 Molecular Biology of Voltage-Gated K+ Channels.- 4 Molecular Biology of High-Conductance, Ca2+-Activated Potassium Channels.- 5 Molecular Biology of Inward Rectifier and ATP-Sensitive Potassium Channels.- 6 Design and Use of Antibodies for Mapping K+ Channel Expression in the Cardiovascular System.- 7 Molecular Methods for Evaluation of K+ Channel Expression and Distribution in the Heart.- 8 Concepts for Patch-Clamp Recording of Whole-Cell and Single-Channel K+ Currents in Cardiac and Vascular Myocytes.- 9 The Patch-Clamp Technique for Measurement of K+ Channels in Xenopus Oocytes and Mammalian Expression Systems.- 10 Heteromultimer Formation in Native K+ Channels.- 11 Use of Transgenic and Gene-Targeted Mice to Study K+ Channel Function in the Cardiovascular System.- 12 Pharmacology of Voltage-Gated K+ Channels.- 13 Pharmacology of High-Conductance, Ca2+ -Activated Potassium Channels.- 14 Pharmacology of Small-Conductance, Calcium-Activated K+ Channels.- 15 Molecular Pharmacology of ATP-Sensitive K+ Channels: How and Why?.- 16 Overview: Molecular Physiology of Cardiac Potassium Channels.- 17 Molecular Mechanisms Controlling Functional Voltage-Gated K+ Channel Diversity and Expression in the Mammalian Heart.- 18 Voltage-Gated Potassium Channels in the Myocardium.- 19 Inward Rectifying and ATP-Sensitive K+ Channels in the Ventricular Myocardium.- 20 Cholinergic and Adrenergic Modulation of Cardiac K+ Channels.- 21 Cardiac K+ Channel Expression and Function at Birth and in the Neonate.- 22 Overview: Physiological Role of K+ Channels in the Regulation of Vascular Tone.- 23 Modulation of Vascular K+ Channels by Extracellular Messengers.- 24 Delayed Rectifier K+ Channels of Vascular Smooth Muscle: Characterization, Function, and Regulation by Phosphorylation.- 25 Potassium Channels in the Circulation of Skeletal Muscle.- 26 Regulation of Cerebral Artery Diameter by Potassium Channels.- 27 The Role of Potassium Channels in the Control of the Pulmonary Circulation.- 28 Potassium Channels in the Renal Circulation.- 29 Potassium Channels in the Coronary Circulation.- 30 Vascular K+ Channel Expression and Function at Birth and in the Neonate.- 31 Overview: Potassium Channels in Vascular Endothelial Cells.- 32 Single-Channel Properties of Ca2+-Activated K+ Channels in the Vascular Endothelium.- 33 Endothelial Cell K+ Channels, Membrane Potential, and the Release of Vasoactive Factors from the Vascular Endothelium.- 34 Activation of Vascular Smooth Muscle K+ Channels by Endothelium-Derived Factors.- 35 Overview: Role of Potassium Channels in Cardiac Arrthythmias.- 36 The Molecular Basis of the Long QT Syndrome.- 37 Altered K+ Channel Expression in the Hypertrophied and Failing Heart.- 38 Role of ATP-Sensitive K+ Channels in Cardiac Preconditioning.- 39 Therapeutic Potential of ATP-Sensitive K+ Channel Openers in Cardiac Ischemia.- 40 Altered Expression and Function of Kv Channels in Primary Pulmonary Hypertension.- 41 Anorectic Drugs and the Vasculature.- 42 Induction of Ca2+-Activated K+ Channel Expression during Systemic Hypertension: Protection against Pathological Vasoconstriction.- 43 Antisense Approaches and the Modulation of Potassium Channel Function in the Cardiovascular System.
1 Evolution of Potassium Channel Proteins.- 2 Three-Dimensional Structure of the K+ Channel Pore: Basis for Ion Selectivity and Permeability.- 3 Molecular Biology of Voltage-Gated K+ Channels.- 4 Molecular Biology of High-Conductance, Ca2+-Activated Potassium Channels.- 5 Molecular Biology of Inward Rectifier and ATP-Sensitive Potassium Channels.- 6 Design and Use of Antibodies for Mapping K+ Channel Expression in the Cardiovascular System.- 7 Molecular Methods for Evaluation of K+ Channel Expression and Distribution in the Heart.- 8 Concepts for Patch-Clamp Recording of Whole-Cell and Single-Channel K+ Currents in Cardiac and Vascular Myocytes.- 9 The Patch-Clamp Technique for Measurement of K+ Channels in Xenopus Oocytes and Mammalian Expression Systems.- 10 Heteromultimer Formation in Native K+ Channels.- 11 Use of Transgenic and Gene-Targeted Mice to Study K+ Channel Function in the Cardiovascular System.- 12 Pharmacology of Voltage-Gated K+ Channels.- 13 Pharmacology of High-Conductance, Ca2+ -Activated Potassium Channels.- 14 Pharmacology of Small-Conductance, Calcium-Activated K+ Channels.- 15 Molecular Pharmacology of ATP-Sensitive K+ Channels: How and Why?.- 16 Overview: Molecular Physiology of Cardiac Potassium Channels.- 17 Molecular Mechanisms Controlling Functional Voltage-Gated K+ Channel Diversity and Expression in the Mammalian Heart.- 18 Voltage-Gated Potassium Channels in the Myocardium.- 19 Inward Rectifying and ATP-Sensitive K+ Channels in the Ventricular Myocardium.- 20 Cholinergic and Adrenergic Modulation of Cardiac K+ Channels.- 21 Cardiac K+ Channel Expression and Function at Birth and in the Neonate.- 22 Overview: Physiological Role of K+ Channels in the Regulation of Vascular Tone.- 23 Modulation of Vascular K+ Channels by Extracellular Messengers.- 24 Delayed Rectifier K+ Channels of Vascular Smooth Muscle: Characterization, Function, and Regulation by Phosphorylation.- 25 Potassium Channels in the Circulation of Skeletal Muscle.- 26 Regulation of Cerebral Artery Diameter by Potassium Channels.- 27 The Role of Potassium Channels in the Control of the Pulmonary Circulation.- 28 Potassium Channels in the Renal Circulation.- 29 Potassium Channels in the Coronary Circulation.- 30 Vascular K+ Channel Expression and Function at Birth and in the Neonate.- 31 Overview: Potassium Channels in Vascular Endothelial Cells.- 32 Single-Channel Properties of Ca2+-Activated K+ Channels in the Vascular Endothelium.- 33 Endothelial Cell K+ Channels, Membrane Potential, and the Release of Vasoactive Factors from the Vascular Endothelium.- 34 Activation of Vascular Smooth Muscle K+ Channels by Endothelium-Derived Factors.- 35 Overview: Role of Potassium Channels in Cardiac Arrthythmias.- 36 The Molecular Basis of the Long QT Syndrome.- 37 Altered K+ Channel Expression in the Hypertrophied and Failing Heart.- 38 Role of ATP-Sensitive K+ Channels in Cardiac Preconditioning.- 39 Therapeutic Potential of ATP-Sensitive K+ Channel Openers in Cardiac Ischemia.- 40 Altered Expression and Function of Kv Channels in Primary Pulmonary Hypertension.- 41 Anorectic Drugs and the Vasculature.- 42 Induction of Ca2+-Activated K+ Channel Expression during Systemic Hypertension: Protection against Pathological Vasoconstriction.- 43 Antisense Approaches and the Modulation of Potassium Channel Function in the Cardiovascular System.
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