Addai-Mensah Donkor

Potential Drug Delivery Agents for Macromolecular Drugs

Cationic Liposomes as Macromolecular Drug Carriers for Gene Therapy and their Biophysical Studies

• Broschiertes Buch

Produktbeschreibung

The theory and principles of gene delivery for therapeutic function have been well documented. Even though viral vectors, weighed against non-viral vectors such as lipoplexes and polyplexes, are far more competent in bringing about cellular transfection, inherent immunity problem compromise their protective use in vivo. Although vulnerabilities consist of mutational insertion hazard and exposure, potentially leading to oncogenicity, large scale production of viral vectors as such might also represent an impediment. Though less efficient, particularly in vivo, both lipoplexes consisting of a complex of nucleic acids and cationic lipids, and polyplexes, composed of cationic polymers and nucleic acids, are considered to be immunologically inert, and importantly safer than viral vectors for in vivo use. In view of the fact that they are also comparatively easy to produce and to amend chemically for enhancement of transfection efficiency, research efforts in this potential area have been significantly augmented over the last decade. Therefore, the accomplishment of non-viral gene therapy depends on a vital approach on novel efficient lipids.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 64
• Erscheinungstermin: 14. September 2011
• Englisch
• Abmessung: 220mm x 150mm x 4mm
• Gewicht: 113g
• ISBN-13: 9783845477848
• ISBN-10: 3845477849
• Artikelnr.: 34102631

Autorenporträt

¿Ph.D. In Pharmaceutics, Long Island Umiversity, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, NY, USA~MSc. Medicinal Chemistry, Long Island University, New York, USA ¿Current Position: Lecturer, University for Development Studies, Department of Applied Chemistry and Biochemistry, Faculty of Applied Sciences, Ghana