Potentially Malignant Disorders of Orofacial Region is a work compiled with a great consideration as oral cancer is a commonly prevailing disease among the world's populations. It is not merely a work nevertheless the result of great dedication, and fortitude. In this field much research has been done and still many more to come because till date, there is no definite method which can pinpoint early cancer. Thus the challenge within the field of oral precancer is to predict which lesion will eventually develop in to carcinoma. After the exhaustive research on clinical, cellular, histopathological and molecular level combined with genetic studies, we have compiled this book with anticipation that data may be engaged in the future for a better understanding of etiopathogenesis of precancer.