Colors have played throughout history and still an important and key role in human life. This importance has been coupled with traditions, customs, ceremonies, and psychotherapy. Color is a key element in design, and has a special significance that is not shared and not matched by any other element of design elements, because each element no matter how important needs to color to get to know it. The sensitivity and response from one to another for colors varies greatly. As it directly affects the human psyche, and activate different feelings in human depths, sadness, tranquility and turbulence. In the current research, we will take light on the effect of colors on the body, the soul and mood, its effectiveness in the treatment of many mental illnesses, and its impact on improving children's behavior. We conducted a field study of patients mentally retardation and autism.