The aim of this book is to provide the needed basic knowledge to use the Matlab-Simulink software on a computer to simulate the modeling and optimization of a single-phase high voltage power supply for industrial microwave generators with N magnetrons 800 Watts-2450 MHz (treated cases N = 1 and N = 2). This original work will contribute to develop of research in the field of manufacturing technology of current single-phase power supplies, three-phase and future hexa-phase with the aim to keep the operating performance of these systems and obtain the following benefits: - Reduction in the cost of producing the installation of the HV power supplies for magnetrons. - Decrease the congestion, volume and cost of maintenance of these installations.