Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) is a protein that in humans is encoded by the PPARGC1A gene.PPARGC1A is also known as human accelerated region 20. It may, therefore, have played a key role in differentiating humans from apes.PGC-1alpha is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with the nuclear receptor PPAR- , which permits the interaction of this protein with multiple transcription factors.
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