Jiapu Zhang

Practical Global Optimization Computing Methods in Molecular Modelling

- for Atomic-resolution Structures of Amyloid Fibrils

• Broschiertes Buch

Produktbeschreibung

Due to the unstable, noncrystalline and insoluble nature of some proteins, the technologies such as X-ray crystallography, NMR (nuclear magnetic resonance) spectroscopy and dual polarization interferometry etc sometimes cannot produce the 3D structures of these proteins. In this condition, molecular modeling (MM) might have been the only strategy to get the 3D structures. The non-covalent interactions such as hydrogen bonding (HB), ionic interactions (SB), Van Der Waals forces (VDW), and hydrophobic packing (HP) are driving the proteins to be able to perform their biological functions. The author has found some SBs play a key role in prion diseases revealed from rabbit prion protein. Neurodegenerative diseases are amyloid fibril diseases. This book studies the HB, VDW, HP interactions for MM of amyloid fibrils in global optimization (GO). The GO MM-algorithms of this book should be very useful in materials science, drug design, IT, operations research, biostatistics and bioinformatics etc research fields. This book was written without advanced mathematical formulas thus it is easily readable for people in wide areas of sciences, engineering, IT, medicine, physiology, education,etc

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Aufl.
• Seitenzahl: 196
• Erscheinungstermin: 13. Oktober 2011
• Englisch
• Abmessung: 220mm x 150mm x 12mm
• Gewicht: 310g
• ISBN-13: 9783846521397
• ISBN-10: 3846521396
• Artikelnr.: 34225638

Autorenporträt

Dr. Jiapu Zhang is a professional "writer" in science, engineering, literature and history, etc. He was born in 1971. He got a bachelor's degree in 1993, and two master's degrees in research in 1996 and 2000 respectively. In 2005 he earned his Ph.D. degree and finished his first postdoc in 2008.